[HTML][HTML] RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
A fraction of cancer cells maintain telomeres through the telomerase-independent, ‘Alternative
Lengthening of Telomeres’ (ALT) pathway. ALT relies on homologous recombination (HR…
Lengthening of Telomeres’ (ALT) pathway. ALT relies on homologous recombination (HR…
[HTML][HTML] FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
Telomerase negative immortal cancer cells elongate telomeres through the Alternative
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required …
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required …
[HTML][HTML] TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
B Silva, R Arora, S Bione, CM Azzalin - Nature communications, 2021 - nature.com
Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-based
mechanism elongating telomeres in a subset of human cancer cells. While the notion that …
mechanism elongating telomeres in a subset of human cancer cells. While the notion that …
[HTML][HTML] Telomerase efficiently elongates highly transcribing telomeres in human cancer cells
BO Farnung, CM Brun, R Arora, LE Lorenzi… - PLoS …, 2012 - journals.plos.org
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a
variety of long non-coding RNA molecules including telomeric repeat-containing RNA (TERRA)…
variety of long non-coding RNA molecules including telomeric repeat-containing RNA (TERRA)…
Telomere elongation chooses TERRA ALTernatives
R Arora, CM Azzalin - RNA biology, 2015 - Taylor & Francis
Alternative Lengthening of Telomeres (ALT) mechanisms allow telomerase-negative
immortal cells to buffer replicative telomere shortening. ALT is naturally active in a number of …
immortal cells to buffer replicative telomere shortening. ALT is naturally active in a number of …
TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops
YW Lee, R Arora, H Wischnewski… - Nature structural & …, 2018 - nature.com
The shelterin protein TRF2 assembles protective T loops at chromosome ends by stimulating
intramolecular invasion of the telomeric G-rich single-stranded DNA (ssDNA) overhang into …
intramolecular invasion of the telomeric G-rich single-stranded DNA (ssDNA) overhang into …
The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restricted
B Silva, R Arora, CM Azzalin - Proceedings of the National …, 2022 - National Acad Sciences
A substantial number of human cancers are telomerase-negative and elongate physiologically
damaged telomeres through a break-induced replication (BIR)-based mechanism known …
damaged telomeres through a break-induced replication (BIR)-based mechanism known …
Translation is required for miRNA‐dependent decay of endogenous transcripts
…, B Abdulkarim, S de Pretis, JY Tan, R Arora… - The EMBO …, 2021 - embopress.org
Post‐transcriptional repression of gene expression by miRNAs occurs through transcript
destabilization or translation inhibition. mRNA decay is known to account for most miRNA‐…
destabilization or translation inhibition. mRNA decay is known to account for most miRNA‐…
[HTML][HTML] The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation
…, H Wischnewski, T Kazeeva, R Arora… - Nature …, 2022 - nature.com
Dead End (DND1) is an RNA-binding protein essential for germline development through
its role in post-transcriptional gene regulation. The molecular mechanisms behind selection …
its role in post-transcriptional gene regulation. The molecular mechanisms behind selection …
Transcription regulates telomere dynamics in human cancer cells
R Arora, CM Brun, CM Azzalin - Rna, 2012 - rnajournal.cshlp.org
Telomeres are nucleoprotein structures capping the physical ends of linear eukaryotic
chromosomes. Although largely heterochromatic, telomeres are transcribed into telomeric repeat-…
chromosomes. Although largely heterochromatic, telomeres are transcribed into telomeric repeat-…