BMDMs are a key model system to study macrophage biology in vitro. Commonly used
methods to differentiate macrophages from BM are treatment with either recombinant M-CSF or …

Methods for rapid identification of chemical tools are essential for the validation of emerging
targets and to provide medicinal chemistry starting points for the development of new …

Matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF) mass spectrometry
has become a promising alternative for high-throughput drug discovery as new instruments …

Post-translational control of proteins through covalent attachment of ubiquitin plays important
roles in all eukaryotic cell functions. The ubiquitin system in humans consists of 2 E1, 35 E2 …

MALDI TOF mass spectrometry (MS) is widely used to characterise and biotype bacterial
samples, but a complementary method for profiling of mammalian cells is still underdeveloped. …

High‐throughput (HT) screening drug discovery, during which thousands or millions of
compounds are screened, remains the key methodology for identifying active chemical matter in …

Chemoproteomics is a powerful method capable of detecting interactions between small
molecules and the proteome; however, its use as a high-throughput screening method for …

MALDI-TOF MS is a powerful analytical technique that provides a fast and label-free readout
for in vitro assays in the high-throughput screening (HTS) environment. Here, we describe …

Inflammatory responses are important in cancer, particularly in the context of monocyte-rich
aggressive myeloid neoplasm. We developed a label-free cellular phenotypic drug discovery …

Inflammatory responses are important in cancer, particularly in the context of monocyte-rich
aggressive myeloid neoplasm. We developed a label-free cellular phenotypic drug discovery …