User profiles for R. Nutiu

Razvan Nutiu

Novartis Institutes for BioMedical Research
Verified email at novartis.com
Cited by 4153

Aptamers with fluorescence-signaling properties

R Nutiu, Y Li - Methods, 2005 - Elsevier
Aptamers are single-stranded DNA or RNA molecules with ligand-binding capabilities.
Signaling aptamers refer to aptamers or modified aptamers with recordable signal generation …

Structure-switching signaling aptamers

R Nutiu, Y Li - Journal of the American Chemical Society, 2003 - ACS Publications
Aptamers are single-stranded nucleic acids with defined tertiary structures for selective binding
to target molecules. Aptamers are also able to bind a complementary DNA sequence to …

[PDF][PDF] In vitro selection of structure‐switching signaling aptamers

R Nutiu, Y Li - Angewandte Chemie International Edition, 2005 - academia.edu
… The reverse primer contained a ribonucleotide (R) at its 3’-end to create a chimeric
antisense strand prone to NaOH-mediated cleavage, which permitted the isolation of the sense …

Structure‐switching signaling aptamers: transducing molecular recognition into fluorescence signaling

R Nutiu, Y Li - Chemistry–A European Journal, 2004 - Wiley Online Library
The development of aptamer technology considerably broadens the utility of nucleic acids
as molecular recognition elements, because it allows the creation of DNA or RNA molecules …

Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument

R Nutiu, RC Friedman, S Luo, I Khrebtukova… - Nature …, 2011 - nature.com
… The average sequencing intensity correlated better with Gcn4p fluorescent intensity for
motif-containing clusters than did the intensity of a labeled primer (R 2 = 0.48 versus 0.30), …

[HTML][HTML] Pervasive regulatory functions of mRNA structure revealed by high-resolution SHAPE probing

…, CE Hajdin, BK Peterson, VM Ruda, N Kubica, R Nutiu… - Cell, 2018 - cell.com
mRNAs can fold into complex structures that regulate gene expression. Resolving such
structures de novo has remained challenging and has limited our understanding of the …

Affinity analysis of a protein− aptamer complex using nonequilibrium capillary electrophoresis of equilibrium mixtures

M Berezovski, R Nutiu, Y Li, SN Krylov - Analytical chemistry, 2003 - ACS Publications
… Using these expressions, we can find the ratio, R, of the two equilibrium fractions: … Wheeler,
Kathryn R. Riley. Silver nanoparticle interactions with glycated and non-glycated human …

Splice site strength–dependent activity and genetic buffering by poly-G runs

X Xiao, Z Wang, M Jang, R Nutiu, ET Wang… - Nature structural & …, 2009 - nature.com
Pre-mRNA splicing is regulated through the combinatorial activity of RNA motifs, including
splice sites and splicing regulatory elements. Here we show that the activity of the G-run (…

Adsorption and covalent coupling of ATP-binding DNA aptamers onto cellulose

S Su, R Nutiu, CDM Filipe, Y Li, R Pelton - Langmuir, 2007 - ACS Publications
… The activity was measured using an anti-ATP structure-switching signaling aptamer
developed by Nutiu and Li. In this approach, illustrated in Figure 1, a duplex is made from an …

Basestock oils for lubricants from mixtures of corn oil and synthetic diesters

…, C Puşcaş, G Bandur, G Vlase, R Nuţiu - Journal of the American Oil …, 2008 - Springer
Environmentally friendly vegetable oils and their derivatives represent alternatives to
mineral-based lubricants. Vegetable oils have high biodegradability and low production costs. …