… Scheme 1 General reaction scheme of a covalent binding interaction between a receptor
(R) and inhibitor (I). Inset image describes the relationship between ligand residence time (τ) …

In the past decades, studies of the Janus kinases (JAKs) and signal transducers and activators
of transcription (STATs) signaling have uncovered highly conserved programs linking …

Eosinophilia and eosinophil activation are recurrent features in various reactive states and
certain hematologic malignancies. In patients with hypereosinophilia (HE), HE‐induced …

Stats (signal transducers and activators of transcription) regulate multiple aspects of T-cell
fate. T regulatory (Treg) cells are a critical subset that limits immune responses, but the …

Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice deficient in
both genes lack all growth hormone and prolactin functions but retain functions associated …

Colorectal carcinoma (CRC) is a major cause of morbidity and mortality in Western countries.
It has so far been molecularly defined mainly by alterations of the Wnt pathway. We show …

In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels
in lymphoid malignancies. In a model for p185 BCR-ABL+ B-acute lymphoid leukemia, we …

Metastasis is the major cause of cancer morbidity, but strategies for direct interference with
invasion processes are lacking. Dedifferentiated, late-stage tumor cells secrete multiple …

Glucocorticoids (GCs) are widely used in the treatment of allergic skin conditions despite
having numerous side effects. Here we use Cre/loxP-engineered tissue-and cell-specific and …

… We termed them S5 R and cS5 F , carrying the single point mutations H 299 →R or S 711
→F. The cS5 F mutant converts Stat5a to a constitutively active mutant, and as a control for cS5 …