Background Measuring disease and injury burden in populations requires a composite metric
that captures both premature mortality and the prevalence and severity of ill-health. The …

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

Background Health system planning requires careful assessment of chronic kidney disease
(CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-…

Background In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9%
of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise …

Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
genome are expected to be either deleterious and swiftly purged or relatively neutral, a …

The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

Background Regularly updated data on stroke and its pathological types, including data on
their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are …

Background Given the projected trends in population ageing and population growth, the
number of people with dementia is expected to increase. In addition, strong evidence has …

Background Non-fatal health outcomes from diseases and injuries are a crucial consideration
in the promotion and monitoring of individual and population health. The Global Burden of …

Background : The burden of cardiovascular diseases (CVDs) remains unclear in many regions
of the world. Objectives : The GBD (Global Burden of Disease) 2015 study integrated data …