Primary ciliary dyskinesia (PCD) is a genetically heterogeneous inherited disorder arising
from dysmotility of motile cilia and sperm. This is associated with a variety of ultrastructural …

10.7554/eLife.11994.001 A major constraint on the evolution of large body sizes in animals
is an increased risk of developing cancer. There is no correlation, however, between body …

The origins and evolution of higher cognitive functions, including complex forms of learning,
attention and executive functions, are unknown. A potential mechanism driving the evolution …

The extensive similarities between the genomes of human and model organisms are the
foundation of much of modern biology, with model organism experimentation permitting …

The association between poor paternal diet, perturbed embryonic development, and adult
offspring ill health represents a new focus for the Developmental Origins of Health and …

A previously unidentified sequence motif has been identified in the products of genes mutated
in Miller-Dieker lissencephaly, Treacher Collins, oral–facial–digital type 1 and contiguous …

Understanding the origins and evolution of synapses may provide insight into species
diversity and the organization of the brain. Using comparative proteomics and genomics, we …

Defects in motile cilia and sperm flagella cause primary ciliary dyskinesia (PCD), characterized
by chronic airway disease, infertility, and left-right laterality disturbances, usually as a …

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder caused by cilia and
sperm dysmotility. About 12% of cases show perturbed 9+2 microtubule cilia structure and …

… (RD Emes and SGN Grant, manuscript in preparation). These genes may be candidates
that underlie clade-specific adaptive evolution and may underpin more subtle differences in …