Viral replication usually requires that innate intracellular lines of defence be overcome, a
task usually accomplished by specialized viral gene products. The virion infectivity factor (Vif) …

To replicate efficiently, viruses must overcome innate defense mechanisms. Human APOBEC3G
is a cytidine deaminase that represents one such barrier, conferring broad intracellular …

Physical interactions between proteins are essential for most biological processes governing
life 1 . However, the molecular determinants of such interactions have been challenging to …

APOBEC3G (also known as CEM15) is an innate intracellular antiretroviral factor that is
counteracted by the Vif protein of lentiviruses. While APOBEC3G orthologues from several …

Mobile elements are important evolutionary forces that challenge genomic integrity. Long
interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still …

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of
transposable elements (TEs), which they repress with their cofactor KAP1 through histone and …

Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene
expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling …

During the early phase of the retroviral life cycle, only a fraction of internalized virions end
up integrating their genome into the chromosome, even though the resulting proviruses are …

The membrane of human immunodeficiency virus type 1 (HIV-1) virions contains high levels
of cholesterol and sphingomyelin, an enrichment that is explained by the preferential …

Reverse transcription-derived sequences account for at least half of the human genome.
Although these retroelements are formidable motors of evolution, they can occasionally cause …