MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma (HNSCC).
Unexpectedly, MAPK pathway aberrations are associated with remarkably long patient …

Head and neck squamous cell carcinoma (HNSCC) lacks predictive biomarkers for drug
responses. By targeted sequencing, we identified two MAPK1 mutations in recurrent HNSCC, …

Soft tissue sarcoma of the tongue represents a very rare head and neck cancer with connective
tissue features, and the genetics underlying this rare cancer are largely unknown. There …

Simple Summary Head and neck cancer (HNC), once metastasized, is very difficult to treat
as there are limited therapy options. Animal models of such can be very useful for preclinical …

RAC1 is a small GTPase with known oncogenicity. Mutations of RAC1 are highly relevant to
melanoma. Yet, little is known about RAC1 aberrations in other human cancers, including …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase encoded by the gene ALK,
which belongs to a subfamily of the insulin receptor superfamily. ALK signaling has been …

Recent genomic characterization studies have demonstrated the genetic heterogeneity of
head and neck squamous cell carcinoma (HNSCC). Yet, most of these genetic aberrations …

Head and neck squamous carcinoma (HNSCC) is an aggressive cancer with few treatment
options. Its well-known genetic heterogeneity presents a major challenge for precision …

Head and neck squamous carcinoma (HNSCC) is a cancer with high genetic heterogeneity.
Fusions of Anaplastic Lymphoma Kinase (ALK) have been widely described as a functional …

… Peony Hiu Yan Poon … Hoi Lam Ngan, Peony Hiu Yan Poon, Yu-Xiong Su, Jason Yik Kuen
Chan, Kwok-… Li, Chin Wang Lau, Wenying Piao, Vivian Wai Yan Lui; Abstract 1792: MAPK1 p.…