Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis‐4 score and aspartate …

…, PV Valli, A Kröger, I Bergamin, P Künzler… - Liver …, 2017 - Wiley Online Library
Background Novel direct antiviral agents ( DAA ) targeting hepatitis C virus ( HCV ) have
revolutionized the treatment of chronic hepatitis C infection ( CHC ). Rates of sustained …

Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease

…, C Krieger-Grübel, G Kullak-Ublick, P Künzler… - Clinical …, 2016 - Elsevier
Background & Aims We examined the relationship between symptoms of depression and
anxiety and clinical recurrence of inflammatory bowel disease (IBD) in a large patient cohort. …

Fatigue in inflammatory bowel disease and its impact on daily activities

…, H Köhler, R Koller, C Krieger, P Künzler… - Alimentary …, 2021 - Wiley Online Library
Background Fatigue is a common symptom of chronic inflammation, including inflammatory
bowel disease (IBD), resulting in significant impairment in quality of life. Aims To identify the …

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

…, L Besse, J Cupovic, P Künzler… - Life science …, 2020 - life-science-alliance.org
Infectious complications in patients with cirrhosis frequently initiate episodes of decompensation
and substantially contribute to the high mortality. Mechanisms of the underlying …

Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease

…, G Kullak‐Ublick, P Künzler… - Alimentary …, 2021 - Wiley Online Library
Background Inflammatory bowel disease (IBD) can be exacerbated by stress and depression.
Type D personality, characterised by high negative affectivity and social inhibition, …

Excellent outcome of direct antiviral treatment for chronic hepatitis C in Switzerland

…, PV Valli, I Bergamin, A Kröger, P Künzler… - Swiss medical …, 2018 - zora.uzh.ch
BACKGROUND The introduction of direct acting antivirals (DAAs) for the therapy of chronic
hepatitis C (CHC) has revolutionised treatment and marks a paradigm shift in the approach …

Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease

…, G Kullak‐Ublick, P Künzler… - Alimentary …, 2018 - Wiley Online Library
Background Smoking is a strong environmental factor leading to adverse outcomes in
Crohn's disease, but a more benign course in ulcerative colitis. Several single nucleotide …

A treatment-as-prevention trial to eliminate hepatitis C among men who have sex with men living with human immunodeficiency virus (HIV) in the Swiss HIV Cohort …

…, C Grube, H Nguyen, P Künzler-Heule… - Clinical infectious …, 2021 - academic.oup.com
Background In 2016, the World Health Organization (WHO) introduced global targets for the
elimination of hepatitis C virus (HCV) by 2030. We conducted a nationwide HCV micro-…

High cure rates with grazoprevir-elbasvir with or without ribavirin guided by genotypic resistance testing among human immunodeficiency virus/hepatitis C virus …

…, A Conen, C Béguelin, P Künzler-Heule… - Clinical infectious …, 2019 - academic.oup.com
Background This study was performed to investigate the efficacy and safety of grazoprevir-elbasvir
guided by baseline resistance-associated substitutions (RASs) in the Swiss HCVree …

Being an informal caregiver for a relative with liver cirrhosis and overt hepatic encephalopathy: a phenomenological study

P Künzler‐Heule, S Beckmann… - Journal of clinical …, 2016 - Wiley Online Library
Aims and objectives To explore the experiences of being an informal caregiver for a relative
with liver cirrhosis and overt hepatic encephalopathy. Background Overt hepatic …