User profiles for Patrick Schreiner

Patrick Schreiner

Booz Allen Hamilton
Verified email at stjude.org
Cited by 1303

[PDF][PDF] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

…, B Sundaram, B Banoth, RKS Malireddi, P Schreiner… - Cell, 2021 - cell.com
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

P Schreiner, X Chen, K Husnjak, L Randles, N Zhang… - Nature, 2008 - nature.com
Targeted protein degradation is largely performed by the ubiquitin–proteasome pathway, in
which substrate proteins are marked by covalently attached ubiquitin chains that mediate …

[HTML][HTML] The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a …

…, G Saccone, M Salvemini, G Savini, P Schreiner… - Genome biology, 2016 - Springer
Background The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive
insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It …

Vaccination versus infection with SARS‐CoV‐2: Establishment of a high avidity IgG response versus incomplete avidity maturation

F Struck, P Schreiner, E Staschik… - Journal of Medical …, 2021 - Wiley Online Library
Avidity is defined as the binding strength of immunoglobulin G (IgG) toward its target epitope.
Avidity is directly related to affinity, as both processes are determined by the best fit of IgG …

[PDF][PDF] Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair

SM Downing, PA Schreiner, YD Kwak, Y Li, TI Shaw… - Neuron, 2021 - cell.com
Aicardi-Goutières syndrome (AGS) is a monogenic type I interferonopathy characterized by
neurodevelopmental defects and upregulation of type I interferon signaling and …

[HTML][HTML] MyD88/CD40 signaling retains CAR T cells in a less differentiated state

B Prinzing, P Schreiner, M Bell, Y Fan, G Krenciute… - JCI insight, 2020 - ncbi.nlm.nih.gov
Chimeric antigen receptor (CAR) T cell therapy for solid tumors has shown limited efficacy in
early-phase clinical studies. The majority of CARs encode CD28 and/or 41BB costimulatory …

The challenge of avidity determination in SARS‐CoV‐2 serology

G Bauer, F Struck, P Schreiner… - Journal of Medical …, 2021 - Wiley Online Library
The serological responses towards severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
nucleoprotein, receptor‐binding domain (RBD), and spike protein S1 are …

COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death

…, B Sundaram, B Banoth, RKS Malireddi, P Schreiner… - BioRxiv, 2020 - biorxiv.org
The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is
a critical shortage of proven treatment options and an urgent need to understand the …

[PDF][PDF] Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections

…, D Rubbenstroth, K Schlottau, M Beer, P Schreiner… - Cell Reports …, 2022 - cell.com
Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late
diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of fatal …

[HTML][HTML] Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity

…, PJ Leavey, D Finkelstein, H Jin, PA Schreiner… - Nature …, 2021 - nature.com
PTEN promoter hypermethylation is nearly universal and PTEN copy number loss occurs in
~25% of fusion-negative rhabdomyosarcoma (FN-RMS). Here we show Pten deletion in a …