User profiles for Pascal Schneider
 | Pascal SchneiderDepartment of Immunobiology, University of Lausanne, Switzerland Verified email at unil.ch Cited by 52293 |
[HTML][HTML] Inhibition of death receptor signals by cellular FLIP
The widely expressed protein Fas is a member of the tumour necrosis factor receptor family
which can trigger apoptosis 1 . However, Fas surface expression does not necessarily …
which can trigger apoptosis 1 . However, Fas surface expression does not necessarily …
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
…, A Attinger, S Valitutti, JL Bodmer, P Schneider… - Nature …, 2000 - nature.com
Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis.
Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic …
Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic …
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses,
including cell growth, differentiation, and even death. Here we describe a novel member of …
including cell growth, differentiation, and even death. Here we describe a novel member of …
[PDF][PDF] TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB
P Schneider, M Thome, K Burns, JL Bodmer… - Immunity, 1997 - cell.com
TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2
(DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that …
(DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that …
TRAIL receptor-2 signals apoptosis through FADD and caspase-8
…, N Holler, S Reynard, P Vinciguerra, P Schneider… - Nature cell …, 2000 - nature.com
… Pascal Schneider … Jean-Luc Bodmer, Nils Holler, Séverine Reynard, Patrizia
Vinciguerra, Pascal Schneider & Jürg Tschopp … Pascal Schneider …
Vinciguerra, Pascal Schneider & Jürg Tschopp … Pascal Schneider …
The molecular architecture of the TNF superfamily
JL Bodmer, P Schneider, J Tschopp - Trends in biochemical sciences, 2002 - cell.com
Ligands of the TNF (tumour necrosis factor) superfamily have pivotal roles in the organization
and function of the immune system, and are implicated in the aetiology of several acquired …
and function of the immune system, and are implicated in the aetiology of several acquired …
BAFF AND APRIL: a tutorial on B cell survival
F Mackay, P Schneider, P Rennert… - Annual review of …, 2003 - annualreviews.org
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature
B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity …
B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity …
Cracking the BAFF code
F Mackay, P Schneider - Nature reviews immunology, 2009 - nature.com
The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL (a
proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess …
proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess …
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
…, C Ambrose, M Baetscher, P Schneider… - The Journal of …, 1999 - rupress.org
The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated
production of tumor necrosis factor (TNF) family members appears to be important in …
production of tumor necrosis factor (TNF) family members appears to be important in …
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Viruses have evolved many distinct strategies to avoid the host's apoptotic response 1,2 .
Here we describe a new family of viral inhibitors (v-FLIPs) which interfere with apoptosis …
Here we describe a new family of viral inhibitors (v-FLIPs) which interfere with apoptosis …