Intrahepatic cholangiocarcinoma: prognostic factors after surgical resection
…, S Pachera, A Valdegamberi, P Nicoli… - World journal of …, 2009 - Wiley Online Library
Background Intrahepatic cholangiocarcinoma (ICC) is the second most common primary
liver tumor. The resectability rate is low because at the time of diagnosis this disease is …
liver tumor. The resectability rate is low because at the time of diagnosis this disease is …
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
…, M Cassin, S di Giovine, P Nicoli… - Blood, The Journal …, 2008 - ashpublications.org
Modulating protein ubiquitination via proteasome inhibition represents a promising target
for cancer therapy, because of the higher sensitivity of cancer cells to the cytotoxic effects of …
for cancer therapy, because of the higher sensitivity of cancer cells to the cytotoxic effects of …
Radiofrequency ablation versus surgical resection for the treatment of hepatocellular carcinoma in cirrhosis
…, M D'Onofrio, E Martone, P Nicoli… - Journal of …, 2008 - Elsevier
Background and Aims Percutaneous radiofrequency ablation (RFA) demonstrated good results
for the treatment of hepatocellular carcinoma (HCC) in cirrhotic patients; it is still not clear …
for the treatment of hepatocellular carcinoma (HCC) in cirrhotic patients; it is still not clear …
Dissection of transcriptional and cis‐regulatory control of differentiation in human pancreatic cancer
GR Diaferia, C Balestrieri, E Prosperini, P Nicoli… - The EMBO …, 2016 - embopress.org
The histological grade of carcinomas describes the ability of tumor cells to organize in
differentiated epithelial structures and has prognostic and therapeutic impact. Here, we show that …
differentiated epithelial structures and has prognostic and therapeutic impact. Here, we show that …
L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis
…, P Gerdes, FJ Sanchez-Luque, P Nicoli… - Genome …, 2018 - genome.cshlp.org
The retrotransposon Long Interspersed Element 1 (LINE-1 or L1) is a continuing source of
germline and somatic mutagenesis in mammals. Deregulated L1 activity is a hallmark of …
germline and somatic mutagenesis in mammals. Deregulated L1 activity is a hallmark of …
Identification of MYC-dependent transcriptional programs in oncogene-addicted liver tumors
TR Kress, P Pellanda, L Pellegrinet, V Bianchi, P Nicoli… - Cancer research, 2016 - AACR
Tumors driven by activation of the transcription factor MYC generally show oncogene
addiction. However, the gene expression programs that depend upon sustained MYC activity …
addiction. However, the gene expression programs that depend upon sustained MYC activity …
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma
G Donati, P Nicoli, A Verrecchia… - EMBO Molecular …, 2023 - embopress.org
MYC is a key oncogenic driver in multiple tumor types, but concomitantly endows cancer
cells with a series of vulnerabilities that provide opportunities for targeted pharmacological …
cells with a series of vulnerabilities that provide opportunities for targeted pharmacological …
[HTML][HTML] The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas
The oncogenic transcription factor Myc is required for the progression and maintenance of
diverse tumors. This has led to the concept that Myc itself, Myc-activated gene products, or …
diverse tumors. This has led to the concept that Myc itself, Myc-activated gene products, or …
Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma
M Ravà, A D'Andrea, P Nicoli, I Gritti, G Donati… - Science translational …, 2018 - science.org
High-grade B cell lymphomas with concurrent activation of the MYC and BCL2 oncogenes,
also known as double-hit lymphomas (DHL), show dismal prognosis with current therapies. …
also known as double-hit lymphomas (DHL), show dismal prognosis with current therapies. …
[PDF][PDF] Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
…, F Marocchi, M Melixetian, N Mohammadi, P Nicoli… - Cell Reports, 2022 - cell.com
Deubiquitinating enzymes are key regulators of the ubiquitin-proteasome system and cell
cycle, and their dysfunction leads to tumorigenesis. Our in vivo drop-out screens in patient-…
cycle, and their dysfunction leads to tumorigenesis. Our in vivo drop-out screens in patient-…