Ischemia modified albumin (IMA), as measured using the albumin cobalt binding test, is
currently the most promising biomarker for early detection of ischemia before the onset of …

Aims Predicting survival from peak exercise oxygen uptake (peak VO 2 ) in chronic heart failure
(CHF) is hindered by its reduction if exercise duration is submaximal. The oxygen uptake …

The diagnostic and prognostic power of the fractal complexity measure ‘α’ of detrended
fluctuation analysis (DFA) has remained mysterious because there has been no explanation of …

First identified in the early 1990s, IMA is produced when ischemia stresses released from
hypoxic heart tissue induce modification of circulating albumin. 5, 6 The amino terminal end (N-…

Early diagnosis and treatment are pivotal for patients with acute aortic dissection (AAD). D-dimer
is a rule-out diagnostic test for pulmonary embolism but there is evidence that it may …

BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a novel therapeutic option
for severe aortic stenosis in old patients with high surgical risk. The aim of this study was to …

In chronic heart failure (CHF), the abnormally large ventilatory response to exercise (VE/VCO
2 slope) has 2 conceptual elements: the requirement of restraining arterial partial pressure …

Table 1. Vascular, anti-inflammatory and metabolic effects of exercise training in heart failure.
ñ Decreased oxidative stress ñ Improved vasodilatory capacity and endothelial function ñ …

Background— An important role of the increased stimulation of skeletal muscle ergoreceptors
(intramuscular afferents sensitive to products of muscle work) in the genesis of symptoms …

Skeletal muscle abnormalities are well-established in patients with heart failure from an early
stage in the progression of the disease and contribute to their symptoms and the limitation …