[HTML][HTML] Novel strategies in artificial organ development: what is the future of medicine?

…, K Kosowska, P Cywoniuk, T Dobrzanski, P Turowski… - Micromachines, 2020 - mdpi.com
The technology of tissue engineering is a rapidly evolving interdisciplinary field of science
that elevates cell-based research from 2D cultures through organoids to whole bionic organs. …

[HTML][HTML] Stem cells as a source of pancreatic cells for production of 3D bioprinted bionic pancreas in the treatment of type 1 diabetes

M Wszoła, D Nitarska, P Cywoniuk, M Gomółka, M Klak - Cells, 2021 - mdpi.com
Type 1 diabetes (T1D) is the third most common autoimmune disease which develops due
to genetic and environmental risk factors. Often, intensive insulin therapy is insufficient, and …

Mechanistic determinants of MBNL activity

…, M Michalak, K Taylor, P Cywoniuk… - Nucleic acids …, 2016 - academic.oup.com
… , Nfix also Ldb3 minigenes will be described elsewhere (Cywoniuk et al., unpublished data).
… Whitney U test; ∗ for P < 0.05, ∗∗ for P < 0.01 and ∗∗∗ for P < 0.001. The Spearman's rank …

MBNL1 alternative splicing isoforms play opposing roles in cancer

…, WKL Teo, PA Goy, P Cywoniuk… - Life science …, 2018 - life-science-alliance.org
The extent of and the oncogenic role played by alternative splicing (AS) in cancer are well
documented. Nonetheless, only few studies have attempted to dissect individual gene …

[HTML][HTML] Irradiation with 365 nm and 405 nm wavelength shows differences in DNA damage of swine pancreatic islets

…, T Dobrzański, G Tymicki, P Cywoniuk, P Kowalska… - PLoS …, 2020 - journals.plos.org
Introduction 3D printing is being used more extensively in modern biomedicine. One of the
problems is selecting a proper crosslinking method of bioprinted material. Amongst currently …

[HTML][HTML] Bionic organs: Shear forces reduce pancreatic islet and mammalian cell viability during the process of 3D bioprinting

…, P Kowalska, T Dobrzański, G Tymicki, P Cywoniuk… - Micromachines, 2021 - mdpi.com
… presented was based on the calculated p-value. The p-value was calculated using Fisher’s
exact test. The p-values were considered statistically significant when p < 0.05. All tested …

MBNL splicing activity depends on RNA binding site structural context

K Taylor, ŁJ Sznajder, P Cywoniuk… - Nucleic acids …, 2018 - academic.oup.com
… The radioactivity on the upper nitrocellulose film (representing 32 P-RNA bound to rMBNL1)
and that on a lower nylon film (representing free 32 P-RNA) was quantified for multiple …

[HTML][HTML] Hyaluronic acid and multiwalled carbon nanotubes as bioink additives for cartilage tissue engineering

T Szymański, JA Semba, AA Mieloch, P Cywoniuk… - Scientific Reports, 2023 - nature.com
… as follows: additive vs control: P a < 0.05; P b < 0.01 and P c < 0.001; timepoint vs timepoint
(within the particular additive group): *P < 0.05; **P < 0.01 and ***P < 0.001. Sequences of …

[HTML][HTML] Formulation and evaluation of a bioink composed of alginate, gelatin, and nanocellulose for meniscal tissue engineering

…, AA Mieloch, E Tomaszewska, P Cywoniuk… - … Journal of Bioprinting, 2023 - ncbi.nlm.nih.gov
1The necessity to preserve meniscal function prompts the research and development of novel
treatment options, like three-dimensional (3D) bioprinting. However, bioinks for meniscal …

AON-induced splice-switching and DMPK pre-mRNA degradation as potential therapeutic approaches for Myotonic Dystrophy type 1

…, P Konieczny, P Cywoniuk… - Nucleic Acids …, 2020 - academic.oup.com
Expansion of an unstable CTG repeat in the 3′UTR of the DMPK gene causes Myotonic
Dystrophy type 1 (DM1). CUG-expanded DMPK transcripts (CUG exp ) sequester Muscleblind-…