[HTML][HTML] Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

…, AS Maebius, C Bartholdy, PP Søgaard… - Nature …, 2023 - nature.com
Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory
and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct …

[HTML][HTML] Future perspectives of oral delivery of next generation therapies for treatment of skin diseases

PP Søgaard, M Lind, CR Christiansen, K Petersson… - Pharmaceutics, 2021 - mdpi.com
Gene therapies have conspicuously bloomed in recent years as evidenced by the increasing
number of cell-, gene-, and oligo-based approved therapies. These therapies hold great …

Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE

CH Gregersen, R Mearraoui, PP Søgaard… - European Journal of …, 2024 - Elsevier
Nucleic acid-based therapeutics encapsulated into lipid nanoparticles (LNPs) can potentially
target the root cause of genetic skin diseases. Although nanoparticles are considered …

Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility

PP Søgaard, N Ito, N Sato, Y Fujita… - Life Science …, 2019 - life-science-alliance.org
Epithelial cells form sheets and tubules in various epithelial organs and establish apicobasal
polarity and asymmetric vesicle transport to provide functionality in these structures. …

NAD+: a metabolic knob fine-tuning inflammation during senescence

PP Søgaard, J Gil - Nature Metabolism, 2019 - nature.com
The senescence-associated secretory phenotype (SASP) is responsible for the deleterious
effects of senescent cells in ageing and cancer. A new study shows that NAD+ metabolism …

Polypharmacy: correlations with sex, age and drug regimen A prescription database study: A prescription database study

L Bjerrum, J Søgaard, J Hallas, J Kragstrup - European journal of clinical …, 1998 - Springer
… Our knowledge is sparse with respect to the prevalence of PP in the general population,
the age and sex of PP users and the type of health problem treated. The increased risk for PP

Polypharmacy in general practice: differences between practitioners.

L Bjerrum, J Søgaard, J Hallas, J Kragstrup - British Journal of General …, 1999 - bjgp.org
… It is therefore unlikely that casemix plays an important role for the variation in PP in this study.
… is rather small and may only have little influence on the variation in PP between practices. …

Study of transitions between wetting states on microcavity arrays by optical transmission microscopy

E Søgaard, NK Andersen, K Smistrup, ST Larsen… - Langmuir, 2014 - ACS Publications
In this article, we present a simple and fast optical method based on transmission microscopy
to study the stochastic wetting transitions on micro- and nanostructured polymer surfaces …

Serum procalcitonin in pulmonary tuberculosis

TA Rasmussen, OS Søgaard, C Camara… - … of tuberculosis and …, 2011 - ingentaconnect.com
… PCT and CRP levels were low, but were significantly higher in patients than in controls (PP
= 0.021 for PCT, PP = 0.01), whereas high CRP did not predict mortality rate (P = 0.887).…

Photopheresis in the red man or pre-Sezary syndrome

H Zachariae, P Bjerring, U Brodthagen, H Søgaard - Dermatology, 1995 - karger.com
… The present paper presents our data on the use of photopheresis (PP) in this subgroup. …
figure 2 following 12 courses of PP. All other treatment was discontinued dur ing the use of PP. …