An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Purpose of Review The underlining goal of this review is to offer a concise, detailed look into
current knowledge surrounding transient receptor potential canonical channel 6 (TRPC6) in …

Communication between neuronal and glial cells is important for many brain functions.
Astrocytes can modulate synaptic strength via Ca 2+ -stimulated release of various …

Local, global and propagating calcium (Ca 2+ ) signals provide the substrate for glial
excitability. Here we analyse Ca 2+ permeability of NMDA and P2X 1/5 receptors expressed in …

Voltage-gated Na v channels are required for normal electrical activity in neurons, skeletal
muscle, and cardiomyocytes. In the heart, Na v 1.5 is the predominant Na v channel, and Na v …

Protease-activated receptors (PARs) are members of a well-known family of transmembrane
G protein-coupled receptors (GPCRs). Four PARs have been identified to date, of which …

10.7554/eLife.31684.001 The first point of our body’s contact with tactile stimuli (innocuous
and noxious) is the epidermis, the outermost layer of skin that is largely composed of …

miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small
non-coding gene, which have been suggested to play roles in both immune and neuronal …

BACKGROUND AND PURPOSE Astrocytes of the mouse neocortex express functional NMDA
receptors, which are not blocked by Mg 2+ ions. However, the pharmacological profile of …

Injury to podocytes is considered a major contributor to diabetic kidney disease: their loss
causes proteinuria and progressive glomerulosclerosis. Podocyte depletion may result from …