User profiles for Ofer Rog

Ofer Rog

University of Utah
Verified email at utah.edu
Cited by 1306

The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

O Rog, S Köhler, AF Dernburg - Elife, 2017 - elifesciences.org
10.7554/eLife.21455.001 The synaptonemal complex (SC) is a polymer that spans ~100 nm
between paired homologous chromosomes during meiosis. Its striated, periodic …

Let's get physical–mechanisms of crossover interference

L von Diezmann, O Rog - Journal of cell science, 2021 - journals.biologists.com
The formation of crossovers between homologous chromosomes is key to sexual reproduction.
In most species, crossovers are spaced further apart than would be expected if they …

Semi-conservative DNA replication through telomeres requires Taz1

KM Miller, O Rog, JP Cooper - Nature, 2006 - nature.com
Telomere replication is achieved through the combined action of the conventional DNA
replication machinery and the reverse transcriptase, telomerase. Telomere-binding proteins …

[PDF][PDF] Direct visualization reveals kinetics of meiotic chromosome synapsis

O Rog, AF Dernburg - Cell reports, 2015 - cell.com
The synaptonemal complex (SC) is a conserved protein complex that stabilizes interactions
along homologous chromosomes (homologs) during meiosis. The SC regulates genetic …

Identification of novel synaptonemal complex components in C. elegans

…, R Turniansky, P Hoess, J Ries, JG Gall, O Rog… - Journal of Cell …, 2020 - rupress.org
The synaptonemal complex (SC) is a tripartite protein scaffold that forms between homologous
chromosomes during meiosis. Although the SC is essential for stable homologue pairing …

Chromosome pairing and synapsis during Caenorhabditis elegans meiosis

O Rog, AF Dernburg - Current opinion in cell biology, 2013 - Elsevier
Meiosis is the specialized cell division cycle that produces haploid gametes to enable sexual
reproduction. Reduction of chromosome number by half requires elaborate chromosome …

[HTML][HTML] Building the synaptonemal complex: Molecular interactions between the axis and the central region

SG Gordon, O Rog - PLoS Genetics, 2023 - journals.plos.org
The successful delivery of genetic material to gametes requires tightly regulated interactions
between the parental chromosomes. Central to this regulation is a conserved chromosomal …

The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins

Y Kim, SC Rosenberg, CL Kugel, N Kostow, O Rog… - Developmental cell, 2014 - cell.com
Proteins of the HORMA domain family play central, but poorly understood, roles in
chromosome organization and dynamics during meiosis. In Caenorhabditis elegans, four such …

Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis

DJ Wynne, O Rog, PM Carlton, AF Dernburg - Journal of Cell Biology, 2012 - rupress.org
Meiotic chromosome segregation requires homologue pairing, synapsis, and crossover
recombination, which occur during meiotic prophase. Telomere-led chromosome motion has …

[PDF][PDF] Meiotic sister chromatid exchanges are rare in C. elegans

DE Almanzar, SG Gordon, O Rog - Current Biology, 2021 - cell.com
Sexual reproduction shuffles the parental genomes to generate new genetic combinations.
To achieve that, the genome is subjected to numerous double-strand breaks, the repair of …