[HTML][HTML] Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

E Barini, O Antico, Y Zhao, F Asta, V Tucci… - Molecular …, 2016 - Springer
Background Alzheimer disease (AD) and other tauopathies develop cerebral intracellular
inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence suggests …

Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases

…, AJ Fletcher, M Soetens, O Antico… - Proceedings of the …, 2021 - National Acad Sciences
The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves
as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are …

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo

…, DA Di Monte, J Tamjar, O Antico… - Royal Society …, 2018 - royalsocietypublishing.org
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

O Antico, A Ordureau, M Stevens, F Singh… - Science …, 2021 - science.org
How activation of PINK1 and Parkin leads to elimination of damaged mitochondria by
mitophagy is largely based on cell lines with few studies in neurons. Here, we have undertaken …

[PDF][PDF] Functional diversification of SRSF protein kinase to control ubiquitin-dependent neurodevelopmental signaling

…, A Segarra-Fas, G Nardocci, A Cassidy, O Antico… - Developmental cell, 2020 - cell.com
Conserved protein kinases with core cellular functions have been frequently redeployed
during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-…

[HTML][HTML] Whole proteome copy number dataset in primary mouse cortical neurons

O Antico, RS Nirujogi, MMK Muqit - Data in Brief, 2023 - Elsevier
The functional diversity of neurons is specified through their proteome resulting in elaborate
and tightly regulated protein interaction networks and signalling that regulates neuronal …

Discovery and characterization of non-canonical E2 conjugating enzymes

SAA Rehman, ED Nisio, C Cazzaniga, O Antico… - bioRxiv, 2023 - biorxiv.org
E2 conjugating enzymes (E2s) play a central role in the enzymatic cascade that leads to the
attachment of ubiquitin to a substrate. This process, termed ubiquitylation is fundamental for …

Structure-based design and characterization of Parkin-activating mutations

…, N Croteau, MA Eldeeb, O Antico… - Life Science …, 2023 - life-science-alliance.org
Autosomal recessive mutations in the Parkin gene cause Parkinson’s disease. Parkin encodes
an ubiquitin E3 ligase that functions together with the kinase PINK1 in a mitochondrial …

[PDF][PDF] Design and high-throughput implementation of MALDI-TOF/MS-based assays for Parkin E3 ligase activity

R Traynor, J Moran, M Stevens, O Antico, A Knebel… - Cell Reports …, 2024 - cell.com
Parkinson's disease (PD) is a progressive neurological disorder that manifests clinically as
alterations in movement as well as multiple non-motor symptoms including but not limited to …

Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue

…, L Petrucelli, M DeTure, DW Dickson, O Antico… - bioRxiv, 2024 - biorxiv.org
The selective removal of dysfunctional mitochondria, a process termed mitophagy, is critical
for cellular health and impairments have been linked to aging, Parkinson disease, and other …