[HTML][HTML] Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
Background Alzheimer disease (AD) and other tauopathies develop cerebral intracellular
inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence suggests …
inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence suggests …
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases
…, AJ Fletcher, M Soetens, O Antico… - Proceedings of the …, 2021 - National Acad Sciences
The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves
as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are …
as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are …
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo
…, DA Di Monte, J Tamjar, O Antico… - Royal Society …, 2018 - royalsocietypublishing.org
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
How activation of PINK1 and Parkin leads to elimination of damaged mitochondria by
mitophagy is largely based on cell lines with few studies in neurons. Here, we have undertaken …
mitophagy is largely based on cell lines with few studies in neurons. Here, we have undertaken …
[PDF][PDF] Functional diversification of SRSF protein kinase to control ubiquitin-dependent neurodevelopmental signaling
…, A Segarra-Fas, G Nardocci, A Cassidy, O Antico… - Developmental cell, 2020 - cell.com
Conserved protein kinases with core cellular functions have been frequently redeployed
during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-…
during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-…
[HTML][HTML] Whole proteome copy number dataset in primary mouse cortical neurons
O Antico, RS Nirujogi, MMK Muqit - Data in Brief, 2023 - Elsevier
The functional diversity of neurons is specified through their proteome resulting in elaborate
and tightly regulated protein interaction networks and signalling that regulates neuronal …
and tightly regulated protein interaction networks and signalling that regulates neuronal …
Discovery and characterization of non-canonical E2 conjugating enzymes
SAA Rehman, ED Nisio, C Cazzaniga, O Antico… - bioRxiv, 2023 - biorxiv.org
E2 conjugating enzymes (E2s) play a central role in the enzymatic cascade that leads to the
attachment of ubiquitin to a substrate. This process, termed ubiquitylation is fundamental for …
attachment of ubiquitin to a substrate. This process, termed ubiquitylation is fundamental for …
Structure-based design and characterization of Parkin-activating mutations
…, N Croteau, MA Eldeeb, O Antico… - Life Science …, 2023 - life-science-alliance.org
Autosomal recessive mutations in the Parkin gene cause Parkinson’s disease. Parkin encodes
an ubiquitin E3 ligase that functions together with the kinase PINK1 in a mitochondrial …
an ubiquitin E3 ligase that functions together with the kinase PINK1 in a mitochondrial …
[PDF][PDF] Design and high-throughput implementation of MALDI-TOF/MS-based assays for Parkin E3 ligase activity
R Traynor, J Moran, M Stevens, O Antico, A Knebel… - Cell Reports …, 2024 - cell.com
Parkinson's disease (PD) is a progressive neurological disorder that manifests clinically as
alterations in movement as well as multiple non-motor symptoms including but not limited to …
alterations in movement as well as multiple non-motor symptoms including but not limited to …
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue
…, L Petrucelli, M DeTure, DW Dickson, O Antico… - bioRxiv, 2024 - biorxiv.org
The selective removal of dysfunctional mitochondria, a process termed mitophagy, is critical
for cellular health and impairments have been linked to aging, Parkinson disease, and other …
for cellular health and impairments have been linked to aging, Parkinson disease, and other …