Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD):
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …

Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

Background A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2)
gene has been reported to be a genetic risk factor for Alzheimer’s disease by two …

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and
cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide …

By analyzing late-onset Alzheimer's disease (LOAD) in a genome-wide association study (313,504
SNPs, three series, 844 cases and 1,255 controls) and evaluating the 25 SNPs with …

APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD).
To address the underlying mechanism, we develop cerebral organoid models using …

Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …

Alzheimer's disease (AD) genetics may be one of the most prolifically published areas in
medicine and biology. Three early-onset AD genes with causative mutations (APP, PSEN1, …

Genetic variants that modify brain gene expression may also influence risk for human
diseases. We measured expression levels of 24,526 transcripts in brain samples from the …