Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ

…, AP Patel, LM Bonilla, N Pierobon, NM Ponzio… - Blood, 2006 - ashpublications.org
Mesenchymal stem cells (MSCs) are mostly found around the vasculature system of the adult
bone marrow (BM). They function as immune suppressors, express MHC-II, are phagocytic, …

Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens

JA Potian, H Aviv, NM Ponzio, JS Harrison… - The Journal of …, 2003 - journals.aai.org
Trans-differentiation of stem cells shows promise for use in tissue repair medicine. Although
poorly defined, mesenchymal stem cells (MSC) appear useful for applications in repair …

Mesenchymal stem cell–derived exosomes stimulate cycling quiescence and early breast cancer dormancy in bone marrow

…, SJ Greco, S Ayer, M Bryan, R Kumar, NM Ponzio… - Cancer research, 2016 - AACR
Dormant breast cancers resurge as metastatic disease after a long dormancy period in the
bone marrow, where cancer cells interact with mesenchymal stem cells (MSC). However, the …

The maternal immune system during pregnancy and its influence on fetal development

…, LT Goldsmith, BN Kashani, NM Ponzio - … and Reports in …, 2015 - Taylor & Francis
The maternal immune system plays a critical role in the establishment, maintenance, and
completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve …

Mesenchymal stem cell–secreted extracellular vesicles instruct stepwise dedifferentiation of breast cancer cells into dormancy at the bone marrow perivascular region

…, Y Naaldijk, S Alonso, P Barak, M Bryan, NM Ponzio… - Cancer research, 2021 - AACR
These findings describe how the initial process of dormancy and dedifferentiation of breast
cancer cells at the bone marrow perivascular niche requires mesenchymal stem cell–derived …

Cytokine levels during pregnancy influence immunological profiles and neurobehavioral patterns of the offspring

NM Ponzio, R Servatius, K Beck… - Annals of the New …, 2007 - Wiley Online Library
The underlying causes of autism spectrum disorders (ASD) are unknown, but clinical and
experimental studies indicate immune mechanisms, in general, and cytokine dysregulation, in …

Teaching medical students to communicate with empathy and clarity using improvisation

…, E Bass, D Killebrew, NM Ponzio… - Academic …, 2018 - journals.lww.com
… NM Ponzio is professor of pathology and laboratory medicine, Rutgers New Jersey
Medical School, Newark, New Jersey. … Wanzer MB, Booth-Butterfield M, Gruber K …

Evidence for the presence of immune dysfunction in chronic fatigue syndrome

…, MH Haghighi, NM Ponzio - Clinical and Vaccine …, 2002 - Am Soc Microbiol
Chronic fatigue syndrome is a medically unexplained ailment characterized by new onset of
fatigue accompanied by rheumatological, infectious, and neuropsychiatric symptoms. …

[HTML][HTML] Exosomes from differentially activated macrophages influence dormancy or resurgence of breast cancer cells within bone marrow stroma

…, M Bryan, M Gergues, OA Sandiford, NM Ponzio… - Cell death & …, 2019 - nature.com
Breast cancer (BC) cells (BCCs) can retain cellular quiescence for decades, a phenomenon
referred to as dormancy. BCCs show preference for the bone marrow (BM) where they can …

[HTML][HTML] Maternal inflammation promotes fetal microglial activation and increased cholinergic expression in the fetal basal forebrain: role of interleukin-6

L Pratt, L Ni, NM Ponzio, GM Jonakait - Pediatric research, 2013 - nature.com
Background: Perinatal exposure to infectious agents with associated maternal immune
activation (MIA) leads to neuroanatomical and behavioral dysregulation reminiscent of autism …