The maintenance of telomere length supports repetitive cell division and therefore plays a
central role in cancer development and progression. Telomeres are extended by either the …

Metastasis is the leading cause of breast cancer-related death and poses a substantial
clinical burden owing to a paucity of targeted treatment options. The clinical manifestations of …

Simple Summary Cells undergoing malignant transformation must circumvent replicative
senescence and eventual cell death associated with progressive telomere shortening that …

Telomerase, a unique reverse transcriptase that specifically extends the ends of linear
chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole …

Despite significant clinical advancements, cancer remains a leading cause of mortality
throughout the world due largely to the process of metastasis and the dissemination of cancer …

The overwhelming majority of cancer-associated morbidity and mortality can be ascribed to
metastasis. Metastatic disease frequently presents in a delayed fashion following initial …

Breast cancer is the most significant cause of cancer-related death in women around the
world. The vast majority of breast cancer-associated mortality stems from metastasis, which …

Tumor dormancy is a major contributor to the lethality of metastatic disease, especially for
cancer patients who develop metastases years-to-decades after initial diagnosis. Indeed, …

Telomeres are structures that cap the ends of linear chromosomes and play critical roles in
maintaining genome integrity and establishing the replicative lifespan of cells. In stem and …

The relationship between telomere homeostasis and the development of cancer remains
incompletely understood. In breast cancer (BC), these knowledge gaps are magnified by the …