User profiles for Nabil Rabhi
nabil rabhiBoston university Verified email at bu.edu Cited by 817 |
[HTML][HTML] Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes
Pancreatic β cell failure leads to diabetes development. During disease progression, β cells
adapt their secretory capacity to compensate the elevated glycaemia and the peripheral …
adapt their secretory capacity to compensate the elevated glycaemia and the peripheral …
[PDF][PDF] Compounds triggering ER stress exert anti-melanoma effects and overcome BRAF inhibitor resistance
…, AS Dabert-Gay, D Debayle, D Alcor, N Rabhi… - Cancer cell, 2016 - cell.com
We have discovered and developed a series of molecules (thiazole benzenesulfonamides).
HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma …
HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma …
[PDF][PDF] Metabolic and innate immune cues merge into a specific inflammatory response via the UPR
Innate immune responses are intricately linked with intracellular metabolism of myeloid cells.
Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis, while …
Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis, while …
Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes
Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes (T2D), are
associated with metastatic breast cancer in postmenopausal women. Here, we investigated …
associated with metastatic breast cancer in postmenopausal women. Here, we investigated …
Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors
Adipose tissue fibrosis is regulated by the chronic and progressive metabolic imbalance
caused by differences in caloric intake and energy expenditure. By exploring the cellular …
caused by differences in caloric intake and energy expenditure. By exploring the cellular …
[HTML][HTML] The adipocyte acquires a fibroblast-like transcriptional signature in response to a high fat diet
Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during
diet-induced obesity. Much is known about the contribution of various stromal vascular cells …
diet-induced obesity. Much is known about the contribution of various stromal vascular cells …
[HTML][HTML] Cofactors as metabolic sensors driving cell adaptation in physiology and disease
Chromatin architectures and epigenetic fingerprint regulation are fundamental for genetically
determined biological processes. Chemical modifications of the chromatin template …
determined biological processes. Chemical modifications of the chromatin template …
[HTML][HTML] Glucose Regulates m6A Methylation of RNA in Pancreatic Islets
F Bornaque, CP Delannoy, E Courty, N Rabhi… - Cells, 2022 - mdpi.com
Type 2 diabetes is characterized by chronic hyperglycemia associated with impaired insulin
action and secretion. Although the heritability of type 2 diabetes is high, the environment, …
action and secretion. Although the heritability of type 2 diabetes is high, the environment, …
[HTML][HTML] Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions
The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a
and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. …
and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. …
[HTML][HTML] Cdkn2a deficiency promotes adipose tissue browning
Objectives Genome-wide association studies have reported that DNA polymorphisms at the
CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) …
CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) …