User profiles for N. Jespersen

Naja Zenius Jespersen

- Verified email at regionh.dk - Cited by 2417

Nichlas Riise Jespersen, MD., PhD.

- Verified email at clin.au.dk - Cited by 1173

Cardiac metabolism as a driver and therapeutic target of myocardial infarction

…, M Ruiz‐Meana, NR Jespersen… - Journal of cellular …, 2020 - Wiley Online Library
Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

[PDF][PDF] A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

NZ Jespersen, TJ Larsen, L Peijs, S Daugaard… - Cell metabolism, 2013 - cell.com
… data set into BATlow (n = 12) and BAThigh (n = 12) groups and assessed established
markers for BAT, WAT, and brite fat. For comparison, we included a WAT sample set (n = 10), ob…

Cardiovascular effects of treatment with the ketone body 3-hydroxybutyrate in chronic heart failure patients

…, HJ Harms, J Frøkiær, H Eiskjaer, NR Jespersen… - Circulation, 2019 - Am Heart Assoc
Background: Myocardial utilization of 3-hydroxybutyrate (3-OHB) is increased in patients with
heart failure and reduced ejection fraction (HFrEF). However, the cardiovascular effects of …

[PDF][PDF] Human brown adipocyte thermogenesis is driven by β2-AR stimulation

…, MC Severinsen, VH Jensen, S Miard, NZ Jespersen… - Cell metabolism, 2020 - cell.com
Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 -…

[PDF][PDF] FGF21 is a sugar-induced hormone associated with sweet intake and preference in humans

S Søberg, CH Sandholt, NZ Jespersen, U Toft… - Cell metabolism, 2017 - cell.com
… Based on sweet-liking scores, we selected the 51 subjects from the highest (n = 25, 19
women and 6 men) and lowest (n = 26, 19 women and 7 men) tertiles of sweet preference and …

[PDF][PDF] Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

…, CH Nielsen, W Orchard, N Willemsen, NZ Jespersen… - Cell, 2021 - cell.com
Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-…

[PDF][PDF] Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis

J Sanchez-Gurmaches, Y Tang, NZ Jespersen… - Cell metabolism, 2018 - cell.com
… from C57BL/6J mice adapted to the indicated temperatures (n = 4). (F) Pathway analysis
of the top 100 most upregulated genes in RT iBAT versus TN (n = 4). AdjP, adjusted p value. …

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

…, EL Van Hauwaert, C Wiwie, NZ Jespersen… - Nature …, 2019 - nature.com
Mesenchymal (stromal) stem cells (MSCs) constitute populations of mesodermal multipotent
cells involved in tissue regeneration and homeostasis in many different organs. Here we …

[PDF][PDF] Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis

…, M Lundh, K Plucinska, NZ Jespersen… - Cell metabolism, 2018 - cell.com
… from control and AdCKO mice (n = 6 per group, t tests, p < 0.05). (B) Daily RQ for control
and AdCKO mice housed in metabolic cages (n = 6 per group). (C and D) (C) Tissue weights (…

[PDF][PDF] Proteomics-based comparative mapping of the secretomes of human brown and white adipocytes reveals EPDR1 as a novel batokine

AS Deshmukh, L Peijs, JL Beaudry, NZ Jespersen… - Cell Metabolism, 2019 - cell.com
Adipokines secreted from white adipose tissue play a role in metabolic crosstalk and
homeostasis, whereas the brown adipose secretome is less explored. We performed high-…