▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best-…

Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a
series of lineage restriction steps that results in the progressive loss of differentiation …

The existence of a common lymphoid progenitor that can only give rise to T cells, B cells,
and natural killer (NK) cells remains controversial and constitutes an important gap in the …

The γ chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding
and intracellular signal transduction. A monoclonal antibody to the γ chain, TUGm2, inhibited …

Mice lacking functional IL-7 or IL-7Rα genes are severely deficient in developing thymocytes,
T cells, and B cells. IL-7 and IL-7 receptor functions are believed to result in lymphoid cell …

The primary role of cytokines in haemato-lymphopoiesis is thought to be the regulation of cell
growth and survival 1 , 2 , 3 . But the instructive action of cytokines in haematopoiesis has …

The γ chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and
is causatively related to X-linked severe combined immunodeficiency (XSCID), which is …

Interleukin 2 (IL-2), a T cell–derived cytokine, targets a variety of cells to induce their growth,
differentiation, and functional activation. IL-2 inserts signals into the cells through IL-2 …

Interleukin-17 (IL-17) induces the production of granulocyte colony-stimulating factor (G-CSF)
and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …

The coordinated production of leukocytes in bone marrow is crucial for innate and adaptive
immunity. Inflammation alters normal leukocyte production by promoting granulopoiesis over …