Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase
Recent findings suggest important roles for nuclear organization in gene expression. In contrast,
little is known about how nuclear organization contributes to genome stability. Epistasis …
little is known about how nuclear organization contributes to genome stability. Epistasis …
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.
M Tsai-Pflugfelder, LF Liu, AA Liu… - Proceedings of the …, 1988 - National Acad Sciences
Two overlapping cDNA clones encoding human DNA topoisomerase II were identified by
two independent methods. In one, a human cDNA library in phage lambda was screened by …
two independent methods. In one, a human cDNA library in phage lambda was screened by …
Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination
…, V Dion, LR Gehlen, M Tsai-Pflugfelder… - Genes & …, 2012 - genesdev.cshlp.org
Chromatin in the interphase nucleus moves in a constrained random walk. Despite extensive
study, the molecular causes of such movement and its impact on DNA-based reactions are …
study, the molecular causes of such movement and its impact on DNA-based reactions are …
PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL
…, N Delgoshaie, M Tsai-Pflugfelder… - Genes & …, 2016 - genesdev.cshlp.org
High-resolution imaging shows that persistent DNA damage in budding yeast localizes in
distinct perinuclear foci for repair. The signals that trigger DNA double-strand break (DSB) …
distinct perinuclear foci for repair. The signals that trigger DNA double-strand break (DSB) …
[PDF][PDF] Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro
F Martino, S Kueng, P Robinson, M Tsai-Pflugfelder… - Molecular cell, 2009 - cell.com
At yeast telomeres and silent mating-type loci, chromatin assumes a higher-order structure
that represses transcription by means of the histone deacetylase Sir2 and structural proteins …
that represses transcription by means of the histone deacetylase Sir2 and structural proteins …
[PDF][PDF] Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling
Mec1-Ddc2 (ATR-ATRIP) controls the DNA damage checkpoint and shows differential cell-cycle
regulation in yeast. To find regulators of Mec1-Ddc2, we exploited a mec1 mutant that …
regulation in yeast. To find regulators of Mec1-Ddc2, we exploited a mec1 mutant that …
A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.
…, Y Dusserre, M Tsai-Pflugfelder… - Genes & …, 1995 - genesdev.cshlp.org
The molecular mechanisms involved in the regulation of gene expression by transforming
growth factor-beta (TGF-beta) have been analyzed. We show that TGF-beta specifically …
growth factor-beta (TGF-beta) have been analyzed. We show that TGF-beta specifically …
Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance
L Bjergbaek, JA Cobb, M Tsai‐Pflugfelder… - The EMBO …, 2005 - embopress.org
The RecQ helicase Sgs1p forms a complex with the type 1 DNA topoisomerase Top3p that
resolves double Holliday junctions resulting from Rad51‐mediated exchange. We find, …
resolves double Holliday junctions resulting from Rad51‐mediated exchange. We find, …
An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing
…, K Shimada, M Tsai-Pflugfelder… - Proceedings of the …, 2002 - National Acad Sciences
The Dbf4/Cdc7 kinase acts at the level of individual origins to promote the initiation of DNA
replication. We demonstrate through both immunoprecipitation and two-hybrid assays that a …
replication. We demonstrate through both immunoprecipitation and two-hybrid assays that a …
The dynamics of yeast telomeres and silencing proteins through the cell cycle
T Laroche, SG Martin, M Tsai-Pflugfelder… - Journal of structural …, 2000 - Elsevier
Genes integrated near the telomeres of budding yeast have a variegated pattern of gene
repression that is mediated by the silent information regulatory proteins Sir2p, Sir3p, and Sir4p. …
repression that is mediated by the silent information regulatory proteins Sir2p, Sir3p, and Sir4p. …