Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare …

The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of protein …

Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited
Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect …

We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced
putative kinase 1) is activated by mitochondrial depolarization and stimulates the …

Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of
PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro. Elegant …

Several studies suggest that nitric oxide (NO • ) contributes to cell death following activation
of NMDA receptors in cultured cortical, hippocampal, and striatal neurons. In the present …

Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential
quality-control (QC) mechanism of pathophysiological relevance in mammals. However, if and …

Highlights • PINK1-Parkin signalling regulates damage-induced mitochondrial homeostasis.
• PINK1 activation and phosphorylation of ubiquitin and Parkin drive mitochondrial …

Serine phosphorylation is a key post-translational modification that regulates diverse biological
processes. Powerful analytical methods have identified thousands of phosphorylation …

Mutations in the mitochondrial protein kinase PINK 1 are associated with autosomal recessive
Parkinson disease ( PD ). We and other groups have reported that PINK 1 activates Parkin …