The proliferation of large-scale DNA-sequencing projects in recent years has driven a
search for alternative methods to reduce time and cost. Here we describe a scalable, highly …

Telomeres were originally defined as chromosome caps that prevent the natural ends of
linear chromosomes from undergoing deleterious degradation and fusion events. POT1 (…

The hereditary spastic paraplegias (HSPs; Strümpell-Lorrain syndrome, MIM number 18260)
are a diverse class of disorders characterized by insidiously progressive lower-extremity …

The possibility that organophosphorus (OP) compounds contribute to motor neuron disease
(MND) is supported by association of paraoxonase 1 polymorphisms with amyotrophic …

The POT1 (protection of telomeres 1) protein binds the single-stranded overhang at the ends
of chromosomes in diverse eukaryotes. It is essential for chromosome end-protection in the …

Background No adjuvant treatment has been established for patients who remain at high
risk for recurrence after neoadjuvant chemoradiotherapy and surgery for esophageal or …

Background First-line chemotherapy for advanced esophageal squamous-cell carcinoma
results in poor outcomes. The monoclonal antibody nivolumab has shown an overall survival …

The genome is extensively transcribed into long intergenic noncoding RNAs (lincRNAs),
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …

The synergy between structure and dynamics is essential to the function of biological
macromolecules. Thermally driven dynamics on different timescales have been experimentally …

Background First-line chemotherapy for advanced or metastatic human epidermal growth
factor receptor 2 (HER2)-negative gastric or gastro-oesophageal junction adenocarcinoma …