User profiles for Mikhail M Savitski

Mikhail Savitski

EMBL
Verified email at embl.de
Cited by 17126

Mass-spectrometry-based draft of the human proteome

…, H Hahne, AM Gholami, M Lieberenz, MM Savitski… - Nature, 2014 - nature.com
Proteomes are characterized by large protein-abundance differences, cell-type- and time-dependent
expression patterns and post-translational modifications, all of which carry …

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

…, WI Chan, SC Robson, C Chung, C Hopf, MM Savitski… - Nature, 2011 - nature.com
Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene
initiate aggressive forms of leukaemia, which are often refractory to conventional therapies 1 . …

Tracking cancer drugs in living cells by thermal profiling of the proteome

MM Savitski, FBM Reinhard, H Franken, T Werner… - Science, 2014 - science.org
INTRODUCTION Understanding drug mechanism poses the daunting challenge of determining
the affinity of the drug for all potential targets. Drug target engagement can be assessed …

Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present

M Bantscheff, S Lemeer, MM Savitski… - Analytical and bioanalytical …, 2012 - Springer
Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into an …

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

M Bantscheff, C Hopf, MM Savitski, A Dittmann… - Nature …, 2011 - nature.com
The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and
anti-inflammatory properties remains challenging in large part owing to the difficulty of probing …

Bioaccumulation of therapeutic drugs by human gut bacteria

…, M Zimmermann, DC Sévin, F Cabreiro, MM Savitski… - Nature, 2021 - nature.com
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However,
the systematic mapping of the interactions between drugs and bacteria has only started …

[HTML][HTML] Control of protein stability by post-translational modifications

JM Lee, HM Hammarén, MM Savitski… - Nature …, 2023 - nature.com
Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein’s stability. These regions, called …

A new antibiotic selectively kills Gram-negative pathogens

…, S Manuse, M Caboni, M Mori, S Niles, M Ghiglieri… - Nature, 2019 - nature.com
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative
pathogens 1 , 2 . These microorganisms have a highly restrictive permeability barrier, which …

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

…, G Drewes, FBM Reinhard, W Huber, MM Savitski - Nature protocols, 2015 - nature.com
The direct detection of drug-protein interactions in living cells is a major challenge in drug
discovery research. Recently, we introduced an approach termed thermal proteome profiling (…

[HTML][HTML] A scalable approach for protein false discovery rate estimation in large proteomic data sets [s]

MM Savitski, M Wilhelm, H Hahne, B Kuster… - Molecular & Cellular …, 2015 - ASBMB
Calculating the number of confidently identified proteins and estimating false discovery rate (FDR)
is a challenge when analyzing very large proteomic data sets such as entire human …