User profiles for Mikhail M Savitski
Mikhail SavitskiEMBL Verified email at embl.de Cited by 17126 |
Mass-spectrometry-based draft of the human proteome
Proteomes are characterized by large protein-abundance differences, cell-type- and time-dependent
expression patterns and post-translational modifications, all of which carry …
expression patterns and post-translational modifications, all of which carry …
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene
initiate aggressive forms of leukaemia, which are often refractory to conventional therapies 1 . …
initiate aggressive forms of leukaemia, which are often refractory to conventional therapies 1 . …
Tracking cancer drugs in living cells by thermal profiling of the proteome
INTRODUCTION Understanding drug mechanism poses the daunting challenge of determining
the affinity of the drug for all potential targets. Drug target engagement can be assessed …
the affinity of the drug for all potential targets. Drug target engagement can be assessed …
Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present
M Bantscheff, S Lemeer, MM Savitski… - Analytical and bioanalytical …, 2012 - Springer
Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into an …
discovery of fundamental biological processes and, more recently, has also developed into an …
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and
anti-inflammatory properties remains challenging in large part owing to the difficulty of probing …
anti-inflammatory properties remains challenging in large part owing to the difficulty of probing …
Bioaccumulation of therapeutic drugs by human gut bacteria
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However,
the systematic mapping of the interactions between drugs and bacteria has only started …
the systematic mapping of the interactions between drugs and bacteria has only started …
[HTML][HTML] Control of protein stability by post-translational modifications
Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein’s stability. These regions, called …
regulatory domains of target proteins, which control a protein’s stability. These regions, called …
A new antibiotic selectively kills Gram-negative pathogens
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative
pathogens 1 , 2 . These microorganisms have a highly restrictive permeability barrier, which …
pathogens 1 , 2 . These microorganisms have a highly restrictive permeability barrier, which …
Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
The direct detection of drug-protein interactions in living cells is a major challenge in drug
discovery research. Recently, we introduced an approach termed thermal proteome profiling (…
discovery research. Recently, we introduced an approach termed thermal proteome profiling (…
[HTML][HTML] A scalable approach for protein false discovery rate estimation in large proteomic data sets [s]
Calculating the number of confidently identified proteins and estimating false discovery rate (FDR)
is a challenge when analyzing very large proteomic data sets such as entire human …
is a challenge when analyzing very large proteomic data sets such as entire human …