Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms involved
are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized that …

Over the past decade, the data-independent acquisition mode has gained popularity for
broad coverage of complex proteomes by LC-MS/MS and quantification of low-abundance …

Secreted phospholipase A 2-IIA (sPLA 2-IIA) hydrolyzes phospholipids to liberate lysophospholipids
and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in …

Fast identification of microbial species in clinical samples is essential to provide an
appropriate antibiotherapy to the patient and reduce the prescription of broad-spectrum …

Despite the central importance of noncoding DNA to gene regulation and evolution, understanding
of the extent of selection on plant noncoding DNA remains limited compared to that of …

The identification of biomarker signatures in omics molecular profiling is usually performed
to predict outcomes in a precision medicine context, such as patient disease susceptibility, …

MicroRNAs (miRNAs) are short RNA species derived from hairpin-forming miRNA precursors
(pre-miRNA) and acting as key posttranscriptional regulators. Most computational tools …

Background Perturbation of the major UGT2B17-dependent androgen catabolism pathway
has the potential to affect prostate cancer (PCa) progression. The objective was to evaluate …

Sex differences in multiple sclerosis (MS) incidence and severity have long been recognized.
However, the underlying cellular and molecular mechanisms for why male sex is …

At the heart of the cellular machinery through the regulation of cellular functions, protein-protein
interactions (PPI) have a significant role. PPI can be analysed with network approaches. …