[HTML][HTML] CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice

K Sato, T Sato, M Ohno-Oishi, M Ozawa… - Experimental Eye …, 2021 - Elsevier
Glaucoma is a leading cause of blindness worldwide and is characterized by degeneration
associated with the death of retinal ganglion cells (RGCs). It is believed that glaucoma is a …

The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL‐1α expression via the rho‐ROCK pathway after optic nerve injury

K Sato, M OhnoOishi, M Yoshida, T Sato, T Aizawa… - Glia, 2023 - Wiley Online Library
Resident microglia are important to maintain homeostasis in the central nervous system,
which includes the retina. The retinal microglia become activated in numerous pathological …

[HTML][HTML] Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues

D Hisamatsu, M Ohno-Oishi, S Nakamura… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
The senescence-associated secretory phenotype (SASP) has attracted attention as a
mechanism that connects cellular senescence to tissue dysfunction, and specific SASP factors …

Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells

…, P See, T Kato, T Taida, M Ohno-Oishi… - Life Science …, 2020 - life-science-alliance.org
Acquired immune responses are initiated by activation of CD4 + helper T (Th) cells via
recognition of antigens presented by conventional dendritic cells (cDCs). DCs instruct Th-cell …

[HTML][HTML] Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma

…, R Saito, A Uruno, N Matsukawa, M Ohno-Oishi… - npj Aging, 2023 - nature.com
Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous
humor, including the metabolites it contains, is useful to understand physiological and …

Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells

S Kojo, M Ohno-Oishi, H Wada, S Nieke… - Life Science …, 2020 - life-science-alliance.org
Temporal down-regulation of the CD8 co-receptor after receiving positive-selection signals
has been proposed to serve as an important determinant to segregate helper versus …

Requirement for intron structures in activating the Cd8a locus

…, K Kakugawa, M Ohno-Oishi… - Proceedings of the …, 2018 - National Acad Sciences
During differentiation of CD4 + CD8 + double-positive (DP) thymocytes into the CD4 − CD8
+ single-positive (CD8SP) thymocytes committed to the cytotoxic T cell lineage, Cd8a …

Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s

…, T Kobayashi, W Seo, M Ohno-Oishi… - Life Science …, 2023 - life-science-alliance.org
The genome organizer, special AT-rich binding protein-1 (SATB1), functions to globally
regulate gene networks during primary T cell development and plays a pivotal role in lineage …

A plant-derived antioxidant supplement prevents the loss of retinal ganglion cells in the retinas of NMDA-injured mice

…, N Himori, T Yabana, M Ohno-Oishi… - Clinical …, 2022 - Taylor & Francis
Purpose To investigate the effect of plant-derived antioxidant compounds, identified with
primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic …

The GPR84 molecule is a key mediator of neurotoxic retinal microglia; ripasudil attenuates the disease-associated GPR84 subpopulation after optic nerve injury.

K Sato, M Ohno-Oishi… - … Ophthalmology & Visual …, 2023 - iovs.arvojournals.org
Purpose: The retinal microglia become activated in numerous pathological conditions, but
the molecular signatures of this change are poorly understood. Here, we evaluated activated …