[HTML][HTML] Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases
D Holdhof, PD Johann, M Spohn, M Bockmayr… - Acta …, 2021 - Springer
Atypical teratoid/rhabdoid tumors (ATRTs) are very aggressive childhood malignancies of the
central nervous system. The underlying genetic cause are inactivating bi-allelic mutations …
central nervous system. The underlying genetic cause are inactivating bi-allelic mutations …
[PDF][PDF] Persistent KSHV infection increases EBV-associated tumor formation in vivo via enhanced EBV lytic gene expression
…, A Murer, V Landtwing, I Quast, CT Styles, M Spohn… - Cell host & …, 2017 - cell.com
The human tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated
herpesvirus (KSHV) establish persistent infections in B cells. KSHV is linked to primary effusion …
herpesvirus (KSHV) establish persistent infections in B cells. KSHV is linked to primary effusion …
Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
…, E Krämer, S Schlossarek, M Spohn… - EMBO Molecular …, 2019 - embopress.org
Hypertrophic cardiomyopathy ( HCM ) is a cardiac genetic disease accompanied by structural
and contractile alterations. We identified a rare c.740C>T (p.T247M) mutation in ACTN 2, …
and contractile alterations. We identified a rare c.740C>T (p.T247M) mutation in ACTN 2, …
[HTML][HTML] Targeted HIV-1 latency reversal using CRISPR/Cas9-derived transcriptional activator systems
JK Bialek, GA Dunay, M Voges, C Schäfer, M Spohn… - PloS one, 2016 - journals.plos.org
CRISPR/Cas9 technology is currently considered the most advanced tool for targeted
genome engineering. Its sequence-dependent specificity has been explored for locus-directed …
genome engineering. Its sequence-dependent specificity has been explored for locus-directed …
Evaluation of unbiased next-generation sequencing of RNA (RNA-seq) as a diagnostic method in influenza virus-positive respiratory samples
…, M Lütgehetmann, H Lellek, M Spohn… - Journal of clinical …, 2015 - Am Soc Microbiol
Unbiased nontargeted metagenomic RNA sequencing (UMERS) has the advantage to detect
known as well as unknown pathogens and, thus, can significantly improve the detection of …
known as well as unknown pathogens and, thus, can significantly improve the detection of …
[HTML][HTML] Dose-dependent T-cell dynamics and cytokine cascade following rVSV-ZEBOV immunization
…, T Strecker, M Eickmann, M Lütgehetmann, M Spohn… - …, 2017 - thelancet.com
Background The recent West African Ebola epidemic led to accelerated efforts to test Ebola
vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (…
vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (…
Essential control of early B-cell development by Mef2 transcription factors
…, M Alawi, D Indenbirken, M Spohn… - Blood, The Journal …, 2016 - ashpublications.org
The sequential activation of distinct developmental gene networks governs the ultimate
identity of a cell, but the mechanisms involved in initiating downstream programs are …
identity of a cell, but the mechanisms involved in initiating downstream programs are …
Molecular characterization of histopathological ependymoma variants
JE Neumann, M Spohn, D Obrecht, M Mynarek… - Acta …, 2020 - Springer
According to the WHO classification, ependymal tumors are classified as subependymomas,
myxopapillary ependymomas, classic ependymomas, anaplastic ependymomas, and RELA-…
myxopapillary ependymomas, classic ependymomas, anaplastic ependymomas, and RELA-…
Extremophilic nitrite-oxidizing Chloroflexi from Yellowstone hot springs
E Spieck, M Spohn, K Wendt, E Bock, J Shively… - The ISME …, 2020 - academic.oup.com
Nitrifying microorganisms occur across a wide temperature range from 4 to 84 C and previous
studies in geothermal systems revealed their activity under extreme conditions. Archaea …
studies in geothermal systems revealed their activity under extreme conditions. Archaea …
[PDF][PDF] Persistence of MERS-CoV-spike-specific B cells and antibodies after late third immunization with the MVA-MERS-S vaccine
…, MP Raadsen, AZ Mykytyn, T Koch, M Spohn… - Cell Reports …, 2022 - cell.com
The Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS
coronavirus (MERS-CoV). In follow up to a phase 1 trial, we perform a longitudinal analysis of …
coronavirus (MERS-CoV). In follow up to a phase 1 trial, we perform a longitudinal analysis of …