Recent advances in the analysis of microbial communities colonizing the human body have
identified a resident microbial community in the human urinary tract (UT). Compared to many …

Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant
subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular …

Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated
myofibroblasts are the primary pathological driver of fibrotic progression, yet how various …

The fibrogenic response in tissue-resident fibroblasts is determined by the balance between
activation and repression signals from the tissue microenvironment. While the molecular …

The gut microbiome is a critical modulator of systemic physiology, including infectious
disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli, …

Postmenopausal women are severely affected by recurrent urinary tract infection (rUTI). The
urogenital microbiome is a key component of the urinary environment. However, changes in …

In the last decade, numerous statistical methods have been developed for analyzing
microbiome data generated from high-throughput next-generation sequencing technology. …

Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides composed of
repeating disaccharide units of uronic acid and amino sugars. The luminal surface of the …

Urinary tract infection (UTI) is one of the most common adult bacterial infections and exhibits
high recurrence rates, especially in postmenopausal women. Studies in mouse models …

Enterococcus faecalis is the leading Gram-positive bacterial species implicated in urinary
tract infection (UTI). An opportunistic pathogen, E. faecalis is a commensal of the human …