The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet
have nearly identical DNA binding specificities. To identify mechanisms that facilitate …

Glucocorticoids are stress hormones that elicit cellular responses by binding to the glucocorticoid
receptor, a ligand-activated transcription factor. The exposure of cells to this hormone …

The binding of transcription factors to short recognition sequences plays a pivotal role in
controlling the expression of genes. The sequence and shape characteristics of binding sites …

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic insight
into the genetic factors moderating the impact of stress can increase our understanding of …

Results Identification of Allele-Specific Regulatory Elements Modulated by a Glucocorticoid
Receptor Agonist in Response to Stress Using STARR-seq. We conducted an enhancer …

The glucocorticoid receptor (GR), a hormone-activated transcription factor, binds to a myriad
of genomic binding sites yet seems to regulate a much smaller number of genes. Genome-…

The transcription factor GATA2 is required for expansion and differentiation of hematopoietic
stem cells (HSCs). In mesenchymal stem cells (MSCs), GATA2 blocks adipogenesis, but its …

Exposure to stressful events increases risk for psychiatric disorders. Mechanistic insight into
genetic factors moderating the impact of stress can increase our understanding of disease …

… Melissa Bothe1 and Edda G. Schulz1,* 1Max Planck Institute for Molecular Genetics,
Ihnestraße 63-67, 14195 Berlin, Germany *Correspondence: edda.schulz@molgen.mpg.de …

The capacity of cells to retain a memory of previous signals enables them to adopt unique
cell fates and adjust to their surrounding environment. The underlying gene expression …