Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

M Schuldiner, O Yanuka… - Proceedings of the …, 2000 - National Acad Sciences
Human embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of in
vitro fertilized human blastocysts. We examined the potential of eight growth factors [basic …

[HTML][HTML] Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile

M Schuldiner, SR Collins, NJ Thompson, V Denic… - Cell, 2005 - cell.com
We present a strategy for generating and analyzing comprehensive genetic-interaction
maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of …

An ER-mitochondria tethering complex revealed by a synthetic biology screen

B Kornmann, E Currie, SR Collins, M Schuldiner… - science, 2009 - science.org
Communication between organelles is an important feature of all eukaryotic cells. To uncover
components involved in mitochondria/endoplasmic reticulum (ER) junctions, we screened …

Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum

…, B Schwappach, P Walter, JS Weissman, M Schuldiner - science, 2009 - science.org
Protein folding in the endoplasmic reticulum is a complex process whose malfunction is
implicated in disease and aging. By using the cell's endogenous sensor (the unfolded protein …

[HTML][HTML] Coming together to define membrane contact sites

…, H Stenmark, C Ungermann, M Schuldiner - Nature …, 2019 - nature.com
Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites has …

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

…, A Roguev, J Fillingham, CS Chu, M Schuldiner… - Nature, 2007 - nature.com
Defining the functional relationships between proteins is critical for understanding virtually
all aspects of cell biology. Large-scale identification of protein complexes has provided one …

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome

DK Breslow, DM Cameron, SR Collins, M Schuldiner… - Nature …, 2008 - nature.com
Functional genomic studies in Saccharomyces cerevisiae have contributed enormously to
our understanding of cellular processes. Their full potential, however, has been hampered by …

[HTML][HTML] Differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers

J Itskovitz-Eldor, M Schuldiner, D Karsenti, A Eden… - Molecular …, 2000 - Springer
Background Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts.
The murine ES cells were demonstrated to be true pluripotent cells as they differentiate into all …

[HTML][HTML] A dynamic interface between vacuoles and mitochondria in yeast

…, V Shinder, AH Futerman, T Geiger, M Schuldiner - Developmental cell, 2014 - cell.com
Cellular life depends on continuous transport of lipids and small molecules between
mitochondria and the endomembrane system. Recently, endoplasmic reticulum-mitochondrial …

[HTML][HTML] Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

…, SH Ahn, V Podolny, SR Collins, M Schuldiner… - Cell, 2005 - cell.com
The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …