User profiles for Mattias Rydenfelt
Mattias RydenfeltCharité Universitätsmedizin Berlin Verified email at charite.de Cited by 550 |
[HTML][HTML] The transcription factor titration effect dictates level of gene expression
…, FM Weinert, HG Garcia, D Song, M Rydenfelt… - Cell, 2014 - cell.com
Models of transcription are often built around a picture of RNA polymerase and transcription
factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between …
factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between …
[HTML][HTML] Classification of gene signatures for their information value and functional redundancy
Gene signatures are more and more used to interpret results of omics data analyses but
suffer from compositional (large overlap) and functional (correlated read-outs) redundancy. …
suffer from compositional (large overlap) and functional (correlated read-outs) redundancy. …
SPEED2: inferring upstream pathway activity from differential gene expression
M Rydenfelt, B Klinger, M Klünemann… - Nucleic acids …, 2020 - academic.oup.com
Extracting signalling pathway activities from transcriptome data is important to infer mechanistic
origins of transcriptomic dysregulation, for example in disease. A popular method to do …
origins of transcriptomic dysregulation, for example in disease. A popular method to do …
Scaling of gene expression with transcription-factor fugacity
The proteins associated with gene regulation are often shared between multiple pathways
simultaneously. By way of contrast, models in regulatory biology often assume these …
simultaneously. By way of contrast, models in regulatory biology often assume these …
Statistical mechanical model of coupled transcription from multiple promoters due to transcription factor titration
Transcription factors (TFs) with regulatory action at multiple promoter targets is the rule rather
than the exception, with examples ranging from the cAMP receptor protein (CRP) in E. coli …
than the exception, with examples ranging from the cAMP receptor protein (CRP) in E. coli …
[HTML][HTML] The Influence of Promoter Architectures and Regulatory Motifs on Gene Expression in Escherichia coli
The ability to regulate gene expression is of central importance for the adaptability of living
organisms to changes in their external and internal environment. At the transcriptional level, …
organisms to changes in their external and internal environment. At the transcriptional level, …
Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
P Riemer, M Rydenfelt, M Marks, K van Eunen… - Journal of Cell …, 2017 - rupress.org
Colorectal cancer is driven by cooperating oncogenic mutations. In this study, we use
organotypic cultures derived from transgenic mice inducibly expressing oncogenic β-catenin and/…
organotypic cultures derived from transgenic mice inducibly expressing oncogenic β-catenin and/…
The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs
M Rydenfelt, M Wongchenko, B Klinger… - Life Science …, 2019 - life-science-alliance.org
Tumors of different molecular subtypes can show strongly deviating responses to drug
treatment, making stratification of patients based on molecular markers an important part of …
treatment, making stratification of patients based on molecular markers an important part of …
Tracking Price Trends Using User–Product Interaction Data From a Price Comparison Service
M Rydenfelt - International Conference on Applied Economics, 2021 - Springer
Using online prices has made it possible to estimate inflation rates at a larger scale and
higher time resolution than were previously possible. In this chapter, we introduce a daily …
higher time resolution than were previously possible. In this chapter, we introduce a daily …
[BOOK][B] The Combinatorics of Transcriptional Regulation
M Rydenfelt - 2014 - search.proquest.com
The ability to regulate gene expression is of central importance for the adaptability of living
organisms to changes in their internal and external environment. At the transcriptional level, …
organisms to changes in their internal and external environment. At the transcriptional level, …