User profiles for Matthew Ginley-Hidinger

Matthew Ginley-Hidinger

University of Utah
Verified email at utah.edu
Cited by 99

Lentiviral CRISPR epigenome editing of inflammatory receptors as a gene therapy strategy for disc degeneration

N Farhang, M Ginley-Hidinger, KC Berrett… - Human Gene …, 2019 - liebertpub.com
Degenerative disc disease (DDD) is a primary contributor to low-back pain, a leading cause
of disability. Progression of DDD is aided by inflammatory cytokines in the intervertebral disc …

Synergistic CRISPRa-regulated chondrogenic extracellular matrix deposition without exogenous growth factors

…, B Davis, J Weston, M Ginley-Hidinger… - … Engineering Part A, 2020 - liebertpub.com
Stem cell therapies have shown promise for regenerative treatment for musculoskeletal
conditions, but their success is mixed. To enhance regenerative effects, growth factors are …

Multiplex gene editing to promote cell survival using low-pH clustered regularly interspaced short palindromic repeats activation (CRISPRa) gene perturbation

…, J Weston, B Austin, B Larsen, M Ginley-Hidinger… - Cytotherapy, 2023 - Elsevier
Background aims Lower back pain is the leading cause of disability worldwide and is often
linked to degenerative disc disease (DDD), the breakdown of intervertebral discs. The …

Regulatory sharing between estrogen receptor α bound enhancers

JB Carleton, M Ginley-Hidinger, KC Berrett… - Nucleic acids …, 2020 - academic.oup.com
The human genome encodes an order of magnitude more gene expression enhancers than
promoters, suggesting that most genes are regulated by the combined action of multiple …

Sufficiency analysis of estrogen responsive enhancers using synthetic activators

M Ginley-Hidinger, JB Carleton… - Life science …, 2019 - life-science-alliance.org
Multiple regulatory regions bound by the same transcription factor have been shown to
simultaneously control a single gene’s expression. However, it remains unclear how these …

Precision Modulation of Estrogen-Dependent Gene Expression

MS Ginley-Hidinger - 2023 - search.proquest.com
Spatiotemporal transcriptional control strategies exist in metazoans to prevent disease and
ensure proper cell function. Specific regions of DNA act as hubs for regulatory proteins to …

[HTML][HTML] Sensitivity of the natriuretic peptide/cGMP system to hyperammonaemia in rat C6 glioma cells and GPNT brain endothelial cells

…, T Powles, JS Dennis-Beron, M Ginley-Hidinger… - Cells, 2021 - mdpi.com
C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system
and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production …

[HTML][HTML] Cis-regulatory control of transcriptional timing and noise in response to estrogen

M Ginley-Hidinger, H Abewe, K Osborne… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cis-Regulatory Elements (CREs) control transcription levels, temporal dynamics, and cell-cell
variation-often referred to as transcriptional noise. However, the combination of regulatory …

OR12-04 Regulatory Sharing between Estrogen Receptor Alpha Bound Enhancers

…, J Carleton, M Ginley-Hidinger - Journal of the Endocrine …, 2020 - academic.oup.com
Mammalian genomes encode an order of magnitude more gene expression enhancers than
promoters, suggesting that most genes are regulated by combinations of enhancers. We …

Adaptive threshold and error-correction coding for robust data retrieval in optical media

T Lu, C Costello, M Ginley-Hidinger… - Optical Pattern …, 2015 - spiedigitallibrary.org
Thresholding techniques that account for noise are essential for the efficiency and accuracy
of an optical communication or optical data storage system. Various types of noise in the …