User profiles for Matthew B McNeil
Matthew McNeilUniversity of Otago, Department of Microbiology Verified email at otago.ac.nz Cited by 922 |
Priming in the Type IF CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer
…, C Taylor, JT Chang, MB McNeil… - Nucleic acids …, 2014 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR), in combination with
CRISPR associated (cas) genes, constitute CRISPR-Cas bacterial adaptive immune systems. …
CRISPR associated (cas) genes, constitute CRISPR-Cas bacterial adaptive immune systems. …
[HTML][HTML] The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis
The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of this …
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of this …
[HTML][HTML] An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis
Increasing antimicrobial resistance compels the search for next-generation inhibitors with
differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium …
differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium …
[HTML][HTML] SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria
Conserved uncharacterized genes account for ∼30% of genes in both eukaryotic and
bacterial genomes and are predicted to encode what are often termed "conserved hypothetical …
bacterial genomes and are predicted to encode what are often termed "conserved hypothetical …
PigS and PigP Regulate Prodigiosin Biosynthesis in Serratia via Differential Control of Divergent Operons, Which Include Predicted Transporters of Sulfur-Containing …
T Gristwood, MB McNeil, JS Clulow… - Journal of …, 2011 - Am Soc Microbiol
Serratia sp. strain ATCC 39006 produces the red-pigmented antibiotic prodigiosin.
Regulation of prodigiosin biosynthesis involves a complex hierarchy, with PigP a master …
Regulation of prodigiosin biosynthesis involves a complex hierarchy, with PigP a master …
Utilization of CRISPR Interference To Validate MmpL3 as a Drug Target in Mycobacterium tuberculosis
There is an urgent need for novel therapeutics to treat Mycobacterium tuberculosis infections.
Genetic strategies for validating novel targets are available, yet their time-consuming …
Genetic strategies for validating novel targets are available, yet their time-consuming …
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
MB McNeil, DD Dennison, CD Shelton… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis
infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (…
infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (…
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA
Y Xia, Y Zhou, DS Carter, MB McNeil… - Life Science …, 2018 - life-science-alliance.org
New antitubercular agents are needed to combat the spread of multidrug- and extensively
drug-resistant strains of Mycobacterium tuberculosis. The frontline antitubercular drug …
drug-resistant strains of Mycobacterium tuberculosis. The frontline antitubercular drug …
CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis
MB McNeil, LM Keighley, JR Cook… - Molecular …, 2021 - Wiley Online Library
Mycobacterium tuberculosis remains a leading cause of death for which new drugs are
needed. The identification of drug targets has been advanced by high‐throughput and targeted …
needed. The identification of drug targets has been advanced by high‐throughput and targeted …
Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents
Cellular bioenergetics is an area showing promise for the development of new antimicrobials,
antimalarials and cancer therapy. Enzymes involved in central carbon metabolism and …
antimalarials and cancer therapy. Enzymes involved in central carbon metabolism and …