User profiles for Matthew B McNeil

Matthew McNeil

University of Otago, Department of Microbiology
Verified email at otago.ac.nz
Cited by 922

Priming in the Type IF CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer

…, C Taylor, JT Chang, MB McNeil… - Nucleic acids …, 2014 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR), in combination with
CRISPR associated (cas) genes, constitute CRISPR-Cas bacterial adaptive immune systems. …

[HTML][HTML] The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis

…, CY Cheung, GM Cook, MB McNeil - Nature …, 2023 - nature.com
The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of this …

[HTML][HTML] An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis

…, BJ Buckley, JDA Tyndall, MB McNeil… - Communications …, 2022 - nature.com
Increasing antimicrobial resistance compels the search for next-generation inhibitors with
differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium …

[HTML][HTML] SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria

MB McNeil, JS Clulow, NM Wilf, GPC Salmond… - Journal of Biological …, 2012 - ASBMB
Conserved uncharacterized genes account for ∼30% of genes in both eukaryotic and
bacterial genomes and are predicted to encode what are often termed "conserved hypothetical …

PigS and PigP Regulate Prodigiosin Biosynthesis in Serratia via Differential Control of Divergent Operons, Which Include Predicted Transporters of Sulfur-Containing …

T Gristwood, MB McNeil, JS Clulow… - Journal of …, 2011 - Am Soc Microbiol
Serratia sp. strain ATCC 39006 produces the red-pigmented antibiotic prodigiosin.
Regulation of prodigiosin biosynthesis involves a complex hierarchy, with PigP a master …

Utilization of CRISPR Interference To Validate MmpL3 as a Drug Target in Mycobacterium tuberculosis

MB McNeil, GM Cook - Antimicrobial agents and chemotherapy, 2019 - Am Soc Microbiol
There is an urgent need for novel therapeutics to treat Mycobacterium tuberculosis infections.
Genetic strategies for validating novel targets are available, yet their time-consuming …

In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis

MB McNeil, DD Dennison, CD Shelton… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis
infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (…

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

Y Xia, Y Zhou, DS Carter, MB McNeil… - Life Science …, 2018 - life-science-alliance.org
New antitubercular agents are needed to combat the spread of multidrug- and extensively
drug-resistant strains of Mycobacterium tuberculosis. The frontline antitubercular drug …

CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis

MB McNeil, LM Keighley, JR Cook… - Molecular …, 2021 - Wiley Online Library
Mycobacterium tuberculosis remains a leading cause of death for which new drugs are
needed. The identification of drug targets has been advanced by high‐throughput and targeted …

Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents

K Hards, C Adolph, LK Harold, MB McNeil… - Progress in Biophysics …, 2020 - Elsevier
Cellular bioenergetics is an area showing promise for the development of new antimicrobials,
antimalarials and cancer therapy. Enzymes involved in central carbon metabolism and …