A need exists for seeking effective treatments for castration-resistant prostate cancer (CRPC)
in response to its emergence following androgen deprivation therapy as a major clinical …

Virus infection, such as hepatitis B virus (HBV), occasionally causes endoplasmic reticulum (ER)
stress. The unfolded protein response (UPR) is counteractive machinery to ER stress, …

The spatially organized gene expression program within the liver specifies hepatocyte
functions according to their relative distances to the bloodstream (ie, zonation), contributing to …

Immune responses are different between individuals and personal health histories and unique
environmental conditions should collectively determine the present state of immune cells. …

Background & Aims Tolvaptan, vasopressin V2‐receptor antagonist, has been used for
patients with difficult‐to‐treat ascites in Japan. In this study, we conducted a genome‐wide …

Background: We recently identified 39 human microRNAs, which effectively suppress hepatitis
B virus (HBV) replication in hepatocytes. Chronic HBV infection often results in active, …

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. HCC
is characterized by a poor prognosis and an ever increasing number of scientific studies …

Hepatitis B virus–specific (HBV-specific) CD8+ T cells fail to acquire effector functions after
priming in the liver, but the molecular basis for the dysfunction is poorly understood. By …

Emulsifiers are widely used in food manufacturing, and cell wall mannoproteins from
Saccharomyces cerevisiae, a representative food yeast, have been proposed as potential new …

A previous study revealed that Saccharomyces cerevisiae mcd4Δ, a cell wall mutant with a
defect in the synthesis of the glycosylphosphatidylinositol anchor, has a strong macrophage …