User profiles for Masashi Akiyama

Masashi Akiyama

Professor, Dept of Dermatology, Nagoya University Graduate School of Medicine
Verified email at med.nagoya-u.ac.jp
Cited by 17147

Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009

V Oji, G Tadini, M Akiyama, CB Bardon… - Journal of the American …, 2010 - Elsevier
BACKGROUND: Inherited ichthyoses belong to a large, clinically and etiologically heterogeneous
group of mendelian disorders of cornification, typically involving the entire integument. …

Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus

…, H Wakamatsu, R Aida, T Moriya, M Akiyama… - Genes to …, 2001 - Wiley Online Library
Background There are two main stimuli that entrain the circadian rhythm, the light‐dark cycle
(LD) and restricted feeding (RF). Light‐induced entrainment requires induction of the Per1 …

[HTML][HTML] Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer

M Akiyama, Y Sugiyama-Nakagiri… - The Journal of …, 2005 - Am Soc Clin Investig
Harlequin ichthyosis (HI) is a devastating skin disorder with an unknown underlying cause.
Abnormal keratinocyte lamellar granules (LGs) are a hallmark of HI skin. ABCA12 is a …

Restricted‐feeding‐induced anticipatory activity rhythm is associated with a phase‐shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and …

…, R Aida, T Moriya, M Akiyama… - European Journal of …, 2001 - Wiley Online Library
Daily restricted feeding (RF) can produce food‐entrainable oscillations in both intact and
suprachiasmatic nucleus (SCN)‐lesioned animals. Thus, there are two circadian rhythms, one …

[HTML][HTML] Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation

…, PR Fournie, F Malecaze, EB Lane, M Akiyama… - Cell, 2016 - cell.com
Inflammasome complexes function as key innate immune effectors that trigger inflammation
in response to pathogen- and danger-associated signals. Here, we report that germline …

[PDF][PDF] Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin–extracellular-matrix linker protein UNC-112, causes Kindler syndrome

…, V Wessagowit, N Oyama, M Akiyama… - The American Journal of …, 2003 - cell.com
Kindler syndrome is an autosomal recessive disorder characterized by neonatal blistering,
sun sensitivity, atrophy, abnormal pigmentation, and fragility of the skin. Linkage and …

Adrenergic regulation of clock gene expression in mouse liver

…, M Kobayashi, M Akiyama… - Proceedings of the …, 2003 - National Acad Sciences
A main oscillator in the suprachiasmatic nucleus (SCN) conveys circadian information to the
peripheral clock systems for the regulation of fundamental physiological functions. Although …

Humanization of autoantigen

…, H Nakamura, E Olasz, KB Yancey, M Akiyama… - Nature medicine, 2007 - nature.com
Transmissibility of characteristic lesions to experimental animals may help us understand the
pathomechanism of human autoimmune disease. Here we show that human autoimmune …

[HTML][HTML] The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist

…, H Mizutani, H Iizuka, M Muto, M Akiyama - Journal of Investigative …, 2013 - Elsevier
Generalized pustular psoriasis (GPP) is a rare inflammatory skin disease that can be life-threatening.
Recently, it has been reported that familial GPP is caused by homozygous or …

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

M Akiyama, S Takeda, K Kokame… - Proceedings of the …, 2009 - National Acad Sciences
ADAMTS13 specifically cleaves plasma von Willebrand factor (VWF) and thereby controls
VWF-mediated platelet thrombus formation. Severe deficiencies in ADAMTS13 can cause life-…