Although their etiologies vary, tumors share a common trait: the control of an oncogenic
transcriptional program that is regulated by the interaction of the malignant cells with the stromal …

Fine tuning of the transcriptional program requires the competing action of multiple protein
complexes in a well-organized environment. Genome folding creates proximity between …

Master transcription factors control the transcriptional program and are essential to maintain
cellular functions. Among them, steroid nuclear receptors, such as the estrogen receptor α (…

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer (1). The
molecular pathogenesis of HCC is highly heterogeneous due to the variety of risk factors …

Transcription-factor binding to cis-regulatory regions regulates the gene expression program
of a cell, but occupancy is often a poor predictor of the gene response. Here, we show that …

Waterpipe smoking is an ancient method of tobacco smoking practiced worldwide. There is
a common belief that waterpipe smoking is a safer alternative to cigarette, but many studies …

Gas station attendants are potentially exposed to carcinogenic substances. This study aimed
to evaluate chronic occupational exposed gas station attendant’s according to genetic …

We investigated whether mitochondrial-related genes and proteins are modulated by
hyperglycemia promoted by gestational diabetes (GDM), thereby increasing neonate obesity …

Yeasts have wide applicability in the industrial field, as in the production of enzymes used in
biocatalysts. Biocatalysts are more efficient when compared to chemical catalysts, with …

Cells respond to multiple signals from the environment simultaneously, which often creates
crosstalk between pathways affecting the capacity to adapt to the changing environment. …