Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining
pluripotency and further opens up the possibility of generating patient-specific pluripotent …

Cell surface-bound receptors represent suitable entry sites for gene delivery into cells by
receptor-mediated endocytosis. Here we have taken advantage of the mannose receptor that is …

Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific
immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-…

Mouse and human stem cells with features similar to those of embryonic stem cells have
been derived from testicular cells. Although pluripotent stem cells have been obtained from …

Most current gene transfer methods function satisfactorily in specialized systems involving
established cell lines but are often not applicable with nonadherent, primary hematopoietic …

The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse
and human fibroblasts. We previously described direct reprogramming of adult mouse neural …

We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated
endocytosis to carry DNA macromolecules into cells. We accomplished this by …

Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …

Background— Inflammation has been closely linked to auto-immunogenic processes in
atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I …

A simple system has been designed enabling ultrasensitive on-line detection of fluorescently
labelled macromolecules, eg nucleic acids, proteins and peptides during electrophoretic …