Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic
reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon …

There are two basic mechanisms for the uptake of substances into the cell. Small molecules
such as amino acids, mono-saccharides, and most ions are transported directly across the …

The human asialoglycoprotein receptor (ASGPR), also called hepatic lectin, is an integral
membrane protein and is responsible for the clearance of desialylated, galactose-terminal …

General comment: The sample sizes of the English public use version of the SOEP and the
German DIW version differ by approximately five percent. The exclusion of 5 percent of the …

The complete primary structure (1827 amino acids) of rabbit intestinal pro-sucrase-isomaltase
(pro-SI) was deduced from the sequence of a nearly full-length cDNA. Pro-SI is anchored …

For targeting and integration of proteins into the mammalian endoplasmic reticulum, two
types of signals can be distinguished: those that translocate their C-terminal sequence (…

The liver is one of the main target organs of Marburg virus (MBG), a filovirus causing severe
haemorrhagic fever with a high fatality rate in humans and non-human primates. MBG grown …

Lipid mobilization through fatty acid β-oxidation is a central process essential for energy
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …

We have analyzed in vivo how model signal sequences are inserted and oriented in the
membrane during cotranslational integration into the endoplasmic reticulum. The results are …

The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian
cells are incompletely understood. Here, we show that after reductive challenge the ER …