Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput …

The pentose phosphate pathway ( PPP ) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for …

Background Eukaryotic cells have evolved various response mechanisms to counteract the
deleterious consequences of oxidative stress. Among these processes, metabolic alterations …

We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural
networks and new quantification and signal correction strategies for the processing of data-…

Highlights • 13 C tracer analysis can be used to probe intracellular metabolism in cells. •
Steady state labeling patterns can quantify nutrient contributions. • Steady state labeling …

Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …

The reaction sequences of central metabolism, glycolysis and the pentose phosphate
pathway provide essential precursors for nucleic acids, amino acids and lipids. However, their …

Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs. ). Here we show that SARS-CoV-2, like other viruses, evokes …

Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…