User profiles for Markus Ralser
Markus RalserCharité Berlin & University of Oxford Verified email at charite.de Cited by 18519 |
[PDF][PDF] Severe COVID-19 is marked by a dysregulated myeloid cell compartment
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …
a subset of patients progress to severe disease and respiratory failure. The mechanism …
[PDF][PDF] Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput …
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput …
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
The pentose phosphate pathway ( PPP ) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for …
The PPP is important to maintain carbon homoeostasis, to provide precursors for …
[HTML][HTML] Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
Background Eukaryotic cells have evolved various response mechanisms to counteract the
deleterious consequences of oxidative stress. Among these processes, metabolic alterations …
deleterious consequences of oxidative stress. Among these processes, metabolic alterations …
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural
networks and new quantification and signal correction strategies for the processing of data-…
networks and new quantification and signal correction strategies for the processing of data-…
A roadmap for interpreting 13C metabolite labeling patterns from cells
Highlights • 13 C tracer analysis can be used to probe intracellular metabolism in cells. •
Steady state labeling patterns can quantify nutrient contributions. • Steady state labeling …
Steady state labeling patterns can quantify nutrient contributions. • Steady state labeling …
Understudied proteins: opportunities and challenges for functional proteomics
Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …
focused on a limited set of increasingly well-known proteins while the biological functions of …
Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible A rchean ocean
MA Keller, AV Turchyn, M Ralser - Molecular systems biology, 2014 - embopress.org
The reaction sequences of central metabolism, glycolysis and the pentose phosphate
pathway provide essential precursors for nucleic acids, amino acids and lipids. However, their …
pathway provide essential precursors for nucleic acids, amino acids and lipids. However, their …
[HTML][HTML] Virus-induced senescence is a driver and therapeutic target in COVID-19
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs. ). Here we show that SARS-CoV-2, like other viruses, evokes …
severity of COVID-19 (refs. ). Here we show that SARS-CoV-2, like other viruses, evokes …
[PDF][PDF] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…