Transfer learning enables predictions in network biology
Mapping gene networks requires large amounts of transcriptomic data to learn the connections
between genes, which impedes discoveries in settings with limited data, including rare …
between genes, which impedes discoveries in settings with limited data, including rare …
Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…
[HTML][HTML] Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases
Clinical and epidemiological data suggest that asthma and allergic diseases are associated
and may share a common genetic etiology. We analyzed genome-wide SNP data for …
and may share a common genetic etiology. We analyzed genome-wide SNP data for …
Deep learning enables genetic analysis of the human thoracic aorta
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of
sudden death. We trained a deep learning model to evaluate the dimensions of the ascending …
sudden death. We trained a deep learning model to evaluate the dimensions of the ascending …
Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender
SJ Fleming, MD Chaffin, A Arduini, AD Akkad… - Nature …, 2023 - nature.com
Droplet-based single-cell assays, including single-cell RNA sequencing (scRNA-seq),
single-nucleus RNA sequencing (snRNA-seq) and cellular indexing of transcriptomes and …
single-nucleus RNA sequencing (snRNA-seq) and cellular indexing of transcriptomes and …
Genetic analysis of right heart structure and function in 40,000 people
Congenital heart diseases often involve maldevelopment of the evolutionarily recent right
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …
[HTML][HTML] Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated
with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and …
with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and …
[HTML][HTML] Genomic and metabolic diversity of Marine Group I Thaumarchaeota in the mesopelagic of two subtropical gyres
BK Swan, MD Chaffin, M Martinez-Garcia… - PloS one, 2014 - journals.plos.org
Marine Group I (MGI) Thaumarchaeota are one of the most abundant and cosmopolitan
chemoautotrophs within the global dark ocean. To date, no representatives of this archaeal …
chemoautotrophs within the global dark ocean. To date, no representatives of this archaeal …
[PDF][PDF] Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
Large-scale gene sequencing studies for complex traits have the potential to identify causal
genes with therapeutic implications. We performed gene-based association testing of blood …
genes with therapeutic implications. We performed gene-based association testing of blood …