Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein
response (UPR), a homeostatic response that preserves proteostasis. Intriguingly, via its …

The start of university life demands an adaptation period, which can sometimes have an impact
on the mental health of students. A total of 233 first year psychology students answered a …

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor
aggressiveness. Evidence suggests that the endoplasmic reticulum ( ER ), a major site for protein …

The endoplasmic reticulum (ER)-induced unfolded protein response (ER UPR ) is an adaptive
mechanism that is activated upon accumulation of misfolded proteins in the ER and aims …

Cancer cells are exposed to intrinsic (oncogene) or extrinsic (microenvironmental) challenges,
leading to activation of stress response pathways. The unfolded protein response (UPR) …

Hepatocellular carcinoma (HCC) is the major primary liver cancer. Glypican‐3 (GPC3), one
of the most abnormally expressed genes in HCC, participates in liver carcinogenesis. Based …

Poplars are one of the woody plants that are very sensitive to water stress, which may reduce
the productivity of fast-growing plantations. Poplars can exhibit several drought tolerance …

Anterior gradient 2 ( AGR 2) is a dimeric protein disulfide isomerase family member involved
in the regulation of protein quality control in the endoplasmic reticulum ( ER ). Mouse AGR 2 …

Besides the fact that miR-96 and miR-182 belong to the miR-182/183 cluster, their seed
region (UUGGCA, nucleotides 2–7) is identical suggesting potential common properties in …

MicroRNAs (miRNA) are generally described as negative regulators of gene expression.
However, some evidence suggests that they may also play positive roles. As such, we reported …