Cell surface metalloproteases coordinate signaling during development, tissue homeostasis,
and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage ("shedding") of …

Background Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel
development and maturation. This study evaluates the efficacy of the inhibition of both …

Recent findings regarding Dll4 function in physiological and pathological conditions indicate
that this Notch ligand may constitute an important therapeutic target. Dll4 appears to be a …

Objective Obesity is the result of positive energy balance. It can be caused by excessive
energy consumption but also by decreased energy dissipation, which occurs under several …

Systemic inhibition of Dll4 has been shown to thoroughly reduce cancer metastasis. The
exact cause of this effect and whether it is endothelial mediated remains to be clarified. …

The toll-like receptor 4 (TLR4) is a central regulator of innate immunity that primarily
recognizes bacterial lipopolysaccharide cell wall constituents to trigger cytokine secretion. We …

iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the
proinflammatory cytokine tumor necrosis factor–α (TNF-α) and TNF receptors (TNFRs) from the cell …

Objective The metalloprotease ADAM17 (also called TACE) plays fundamental roles in
homeostasis by shedding key signaling molecules from the cell surface. Although its importance …

The use of immunogenic formulations targeting pattern recognition receptors towards
modulation of immune responses is a promising strategy to develop better vaccines against …

The metalloprotease ADAM17 is a sheddase of key molecules, including TNF and
epidermal growth factor receptor ligands. ADAM17 exists within an assemblage, the “sheddase …