Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells

…, A Hijikata, M Tomizawa-Murasawa… - Science translational …, 2010 - science.org
Human acute myeloid leukemia (AML) originates from rare leukemia stem cells (LSCs).
Because these chemotherapy-resistant LSCs are thought to underlie disease relapse, effective …

Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML

…, S Tanaka, N Suzuki, M Tomizawa-Murasawa… - Nature …, 2010 - nature.com
Cancer stem cells have been proposed to be important for initiation, maintenance and
recurrence of various malignancies, including acute myeloid leukemia (AML) 1 , 2 , 3 . We have …

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

…, N Uchida, M Tomizawa-Murasawa… - Science translational …, 2013 - science.org
Leukemia stem cells (LSCs) that survive conventional chemotherapy are thought to contribute
to disease relapse, leading to poor long-term outcomes for patients with acute myeloid …

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice

…, M Iwasaki, M Tomizawa-Murasawa… - Life science …, 2019 - life-science-alliance.org
The immune system encompasses acquired and innate immunity that matures through
interaction with microenvironmental components. Cytokines serve as environmental factors that …

Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice

Y Najima, M Tomizawa-Murasawa… - Blood, The Journal …, 2016 - ashpublications.org
Induction of specific immune response against therapy-resistant tumor cells can potentially
improve clinical outcomes in malignancies. To optimize immunotherapy in the clinic, we …

[HTML][HTML] Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model

…, E Kawakami, M Iwasaki, M Tomizawa-Murasawa… - …, 2019 - thelancet.com
Background Graft-versus host disease (GVHD) is a complication of stem cell transplantation
associated with significant morbidity and mortality. Non-specific immune-suppression, the …

Cell Cycle Entry Potentiates Elimination of Chemotherapy-Resistant Human AML Stem Cells.

Y Saito, N Uchida, S Tanaka, M Tomizawa-Murasawa… - Blood, 2009 - Elsevier
Abstract 1422 Poster Board I-445 Acute myeloid leukemia (AML) is associated with poor
long-term prognosis despite advances in therapeutic modalities over the past few decades. As …

[HTML][HTML] Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via …

C Onish, S Mori-Kimachi, T Hirade, M Abe… - Journal of Biological …, 2014 - ASBMB
Internal tandem duplication mutations in the Flt3 gene (ITD-FLT3) enhance cell migration
toward the chemokine Cxcl12, which is highly expressed in the therapy-protective bone …

[HTML][HTML] Anti-Vα24Jα18 TCR antibody tunes iNKT cell responses to target and kill CD1d-negative tumors in an FcγRII (CD32)-dependent manner

M Takami, T Aoki, K Nishimura, H Tanaka… - Cancer Research …, 2024 - AACR
Our findings unveiled that iNKT cells recognize and kill CD1d-negative target tumors via the
anti-iNKT TCR mAb bound to CD32 at the tumor site, thereby bridging iNKT cells and CD1d-…

[PDF][PDF] Enhancing T cell receptor stability in rejuvenated iPSC-derived T cells improves their use in cancer immunotherapy

A Minagawa, T Yoshikawa, M Yasukawa, A Hotta… - Cell Stem Cell, 2018 - cell.com
Limited T cell availability and proliferative exhaustion present major barriers to successful T
cell-based immunotherapies and may potentially be overcome through the use of "…