Most human genes encode multiple mRNA variants and protein products through alternative
splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing …

Resistance to chemotherapy is a major complication in the treatment of advanced breast
cancer. Estrogens and prolactin (PRL) are implicated in the pathogenesis of breast cancer but …

Alterations in expression and/or activity of splicing factors as well as mutations in cis-acting
splicing regulatory sequences contribute to cancer phenotypes. Genome-wide studies have …

The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and
its mechanism of action remain unknown. We demonstrate that Sam68 binds the mRNA for …

In most species, the meiotic cell cycle is arrested at the transition between prophase and
metaphase through unclear somatic signals. Activation of the Cdc2-kinase component of …

The Ewing sarcoma (EWS) protein is a member of the TET (TLS/EWS/TAF15) family of RNA-
and DNA-binding proteins whose expression is altered in cancer. We report that EWS …

Human cyclin D1 is expressed as two isoforms derived by alternate RNA splicing, termed
D1a and D1b, which differ for the inclusion of intron 4 in the D1b mRNA. Both isoforms are …

In the mouse, three genes that are homologous to the Drosophila Nanos (Nos) gene have
been identified. Deletion of one of these genes, Nanos2, results in male sterility, owing to loss …

Deregulation of the phosphatidyl inositol trisphosphate kinase/AKT/mammalian target of
rapamycin (mTOR) and RAS/mitogen-activated protein kinase (MAPK)/MNK pathways …

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by loss of motor
neurons in patients with null mutations in the SMN1 gene. An almost identical SMN2 gene is …