User profiles for Maria Colomé-Tatché
Maria Colomé-TatchéHelmholtz Zentrum Muenchen Verified email at helmholtz-muenchen.de Cited by 6302 |
[HTML][HTML] Benchmarking atlas-level data integration in single-cell genomics
Single-cell atlases often include samples that span locations, laboratories and conditions,
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets requires …
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets requires …
Mapping the epigenetic basis of complex traits
Quantifying the impact of heritable epigenetic variation on complex traits is an emerging
challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines …
challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines …
Widespread long-range cis-regulatory elements in the maize genome
…, M Galli, MK Mejía-Guerra, M Colomé-Tatché… - Nature plants, 2019 - nature.com
Genetic mapping studies on crops suggest that agronomic traits can be controlled by gene–distal
intergenic loci. Despite the biological importance and the potential agronomic utility of …
intergenic loci. Despite the biological importance and the potential agronomic utility of …
Ecological plant epigenetics: Evidence from model and non‐model species, and the way forward
Growing evidence shows that epigenetic mechanisms contribute to complex traits, with
implications across many fields of biology. In plant ecology, recent studies have attempted to …
implications across many fields of biology. In plant ecology, recent studies have attempted to …
Rate, spectrum, and evolutionary dynamics of spontaneous epimutations
…, RJ Schmitz, M Colomé-Tatché… - Proceedings of the …, 2015 - National Acad Sciences
Stochastic changes in cytosine methylation are a source of heritable epigenetic and
phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust …
phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust …
[HTML][HTML] Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
Background Chromosome instability leads to aneuploidy, a state in which cells have abnormal
numbers of chromosomes, and is found in two out of three cancers. In a chromosomal …
numbers of chromosomes, and is found in two out of three cancers. In a chromosomal …
Genetic sources of population epigenomic variation
A Taudt, M Colomé-Tatché, F Johannes - Nature Reviews Genetics, 2016 - nature.com
The field of epigenomics has rapidly progressed from the study of individual reference
epigenomes to surveying epigenomic variation in populations. Recent studies in a number of …
epigenomes to surveying epigenomic variation in populations. Recent studies in a number of …
[HTML][HTML] Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons
…, WFA den Dunnen, F Foijer, M Colomé-Tatché… - Genome biology, 2016 - Springer
Background Alzheimer’s disease (AD) is a neurodegenerative disease of the brain and the
most common form of dementia in the elderly. Aneuploidy, a state in which cells have an …
most common form of dementia in the elderly. Aneuploidy, a state in which cells have an …
Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation
M Colomé-Tatché, S Cortijo… - Proceedings of the …, 2012 - National Acad Sciences
The rate of meiotic crossing over (CO) varies considerably along chromosomes, leading to
marked distortions between physical and genetic distances. The causes underlying this …
marked distortions between physical and genetic distances. The causes underlying this …
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes
Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …