An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory
…, M Sanchez, G Borsellino, AN Akbar, M De Bardi… - Nature cell …, 2022 - nature.com
The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …
Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis
…, MV Alfonsi, C Nicoletti, S Gatto, M De Bardi… - Nature cell …, 2018 - nature.com
Fibro-adipogenic progenitors (FAPs) are typically activated in response to muscle injury,
and establish functional interactions with inflammatory and muscle stem cells (MuSCs) to …
and establish functional interactions with inflammatory and muscle stem cells (MuSCs) to …
[HTML][HTML] Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy
Fibro-adipogenic progenitors (FAPs) are currently defined by their anatomical position,
expression of non-specific membrane-associated proteins, and ability to adopt multiple lineages …
expression of non-specific membrane-associated proteins, and ability to adopt multiple lineages …
HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles
…, P Fasanaro, G Borsellino, M De Bardi… - Genes & …, 2014 - genesdev.cshlp.org
Fibro-adipogenic progenitors (FAPs) are important components of the skeletal muscle
regenerative environment. Whether FAPs support muscle regeneration or promote fibro-…
regenerative environment. Whether FAPs support muscle regeneration or promote fibro-…
The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role …
V Chiurchiù, M Lanuti, M De Bardi… - International …, 2015 - academic.oup.com
G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic
cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found …
cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found …
Distinct modulation of human myeloid and plasmacytoid dendritic cells by anandamide in multiple sclerosis
…, MT Cencioni, E Bisicchia, M De Bardi… - Annals of …, 2013 - Wiley Online Library
Objective The immunopathogenesis of multiple sclerosis (MS) has always been thought to
be driven by chronically activated and autoreactive Th‐1 and Th‐17 cells. Recently, dendritic …
be driven by chronically activated and autoreactive Th‐1 and Th‐17 cells. Recently, dendritic …
T helper 9 cells induced by plasmacytoid dendritic cells regulate interleukin-17 in multiple sclerosis
…, C Motta, G Macchiarulo, F Barbieri, M De Bardi… - Clinical …, 2015 - portlandpress.com
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized
by persistent inflammation orchestrated by cluster of differentiation (CD) 4 T helper (Th) …
by persistent inflammation orchestrated by cluster of differentiation (CD) 4 T helper (Th) …
HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells
M Sandonà, S Consalvi, L Tucciarone, M De Bardi… - EMBO …, 2020 - embopress.org
We show that extracellular vesicles (EVs) released by mesenchymal cells (ie, fibro–adipogenic
progenitors—FAPs) mediate microRNA (miR) transfer to muscle stem cells (MuSCs) and …
progenitors—FAPs) mediate microRNA (miR) transfer to muscle stem cells (MuSCs) and …
A Leukemia-Associated CD34/CD123/CD25/CD99+ Immunophenotype Identifies FLT3-Mutated Clones in Acute Myeloid Leukemia
…, S Lavorgna, M Cittadini, F Buccisano, M De Bardi… - Clinical Cancer …, 2015 - AACR
Purpose: We evaluated leukemia-associated immunophenotypes (LAIP) and their correlation
with fms-like tyrosine kinase 3 (FLT3) and nucleophosmin (NPM1) gene mutational status …
with fms-like tyrosine kinase 3 (FLT3) and nucleophosmin (NPM1) gene mutational status …
[HTML][HTML] Proinflammatory mucosal-associated invariant CD8+ T cells react to gut flora yeasts and infiltrate multiple sclerosis brain
…, V Annibali, C Vuotto, M De Bardi… - Frontiers in …, 2022 - frontiersin.org
The composition of the intestinal microbiota plays a critical role in shaping the immune
system. Modern lifestyle, the inappropriate use of antibiotics, and exposure to pollution have …
system. Modern lifestyle, the inappropriate use of antibiotics, and exposure to pollution have …